Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 1754150..1754667 Replicon chromosome
Accession NZ_CP034441
Organism Staphylococcus aureus strain PMB 81-4

Toxin (Protein)


Gene name yoeB Uniprot ID T1YC79
Locus tag EJN89_RS08905 Protein ID WP_000113262.1
Coordinates 1754401..1754667 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag EJN89_RS08900 Protein ID WP_000584499.1
Coordinates 1754150..1754401 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EJN89_RS08870 1749848..1750567 + 720 WP_000479576.1 amino acid ABC transporter permease -
EJN89_RS08875 1750564..1751295 + 732 WP_000615458.1 amino acid ABC transporter ATP-binding protein -
EJN89_RS08880 1751392..1752642 - 1251 WP_001012222.1 FemA/FemB family glycyltransferase FmhA -
EJN89_RS08885 1752897..1753259 + 363 WP_000819843.1 DUF4467 domain-containing protein -
EJN89_RS08890 1753278..1753877 + 600 WP_000162810.1 DsbA family protein -
EJN89_RS08895 1753884..1753985 + 102 Protein_1658 hypothetical protein -
EJN89_RS08900 1754150..1754401 + 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
EJN89_RS08905 1754401..1754667 + 267 WP_000113262.1 Txe/YoeB family addiction module toxin Toxin
EJN89_RS08910 1754961..1756511 + 1551 WP_000727763.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
EJN89_RS08915 1756697..1757164 + 468 WP_000153344.1 SRPBCC domain-containing protein -
EJN89_RS08920 1757248..1757430 + 183 WP_000230294.1 hypothetical protein -
EJN89_RS08925 1757647..1758471 + 825 WP_000572040.1 formate/nitrite transporter family protein -
EJN89_RS08930 1758715..1759242 + 528 WP_000973468.1 GNAT family N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10437.95 Da        Isoelectric Point: 9.9143

>T116038 WP_000113262.1 NZ_CP034441:1754401-1754667 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T116038 NZ_CP034441:1754401-1754667 [Staphylococcus aureus]
ATGGCTAGGTTAAATATTACGTTTTCGCCTCAAGCCTTTGAAGATTATAAGTATTTTCAGCAGAACGATAAAAAAATGGT
GAAGAAAATTAATGAGTTACTTAAAAGTATTGACAGAAATGGTGCATTGGAAGGTATAGGTAAGCCTGAAAAGTTAAAAT
CGAATCTGACTGGGTATTATAGTAGACGTATCAATCACGAACATAGATTGGTTTATACAGTAGATGACAATCATATAAAA
ATAGCATCATGTAAATACCATTATTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT116038 WP_000584499.1 NZ_CP034441:1754150-1754401 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp

>AT116038 NZ_CP034441:1754150-1754401 [Staphylococcus aureus]
ATGATTATTAAAAATTATTCATACGCTCGACAGAATTTAAAGGCACTTATGACAAAAGTAAATGATGATAGTGATATGGT
AACTGTAACATCTACTGATGATAAAAACGTAGTAATCATGTCAGAATCAGATTATAACTCCATGATGGAAACACTTTACC
TCCAACAGAACCCAAATAATGCTGAACACTTAGCTCAATCAATTGCAGATCTAGAACGTGGGAAAACTATAACGAAAGAT
ATAGATGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7CUA
PDB 6L8E

Antitoxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7BWF
PDB 6L8E
AlphaFold DB T1YB60

References