Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) SprA2-SprA2AS/-
Location 1729126..1729310 Replicon chromosome
Accession NZ_CP034441
Organism Staphylococcus aureus strain PMB 81-4

Toxin (Protein)


Gene name SprA2 Uniprot ID A0A2P7CQJ7
Locus tag EJN89_RS08745 Protein ID WP_000482647.1
Coordinates 1729126..1729233 (+) Length 36 a.a.

Antitoxin (RNA)


Gene name SprA2AS
Locus tag -
Coordinates 1729251..1729310 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EJN89_RS08720 1724498..1724971 + 474 WP_000456497.1 GyrI-like domain-containing protein -
EJN89_RS08725 1725094..1726305 - 1212 WP_001192075.1 multidrug effflux MFS transporter -
EJN89_RS08730 1726487..1727146 - 660 WP_000831301.1 membrane protein -
EJN89_RS08735 1727206..1728348 - 1143 WP_001176871.1 glycerate kinase -
EJN89_RS08740 1728606..1728992 + 387 WP_000779360.1 flippase GtxA -
EJN89_RS08745 1729126..1729233 + 108 WP_000482647.1 type I toxin-antitoxin system Fst family toxin Toxin
- 1729251..1729310 - 60 - - Antitoxin
EJN89_RS08755 1729917..1731680 + 1764 WP_001064816.1 ABC transporter ATP-binding protein/permease -
EJN89_RS08760 1731705..1733438 + 1734 WP_125998338.1 ABC transporter ATP-binding protein/permease -
EJN89_RS08770 1733669..1733836 + 168 WP_001790576.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 4012.76 Da        Isoelectric Point: 10.4935

>T116036 WP_000482647.1 NZ_CP034441:1729126-1729233 [Staphylococcus aureus]
MFNLLIDIMTSALSGCLVAFFAHWLRTRNNKKGDK

Download         Length: 108 bp

>T116036 NZ_CP034441:1729126-1729233 [Staphylococcus aureus]
ATGTTCAATTTATTAATTGACATCATGACTTCAGCTTTAAGCGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAACAATAAAAAAGGTGACAAATAA

Antitoxin


Download         Length: 60 bp

>AT116036 NZ_CP034441:c1729310-1729251 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P7CQJ7

Antitoxin

Download structure file

References