Detailed information of TA system TA116036

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-SprA2AS/-
• Location: 1729126..1729310
• Replicon: chromosome
• Accession: NZ_CP034441
• Organism: Staphylococcus aureus strain PMB 81-4

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: A0A2P7CQJ7
• Locus tag: EJN89_RS08745
• Protein ID: WP_000482647.1
• Coordinates: 1729126..1729233 (+)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	1729251..1729310 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EJN89_RS08720	1724498..1724971	+	474	WP_000456497.1	GyrI-like domain-containing protein	-
EJN89_RS08725	1725094..1726305	-	1212	WP_001192075.1	multidrug effflux MFS transporter	-
EJN89_RS08730	1726487..1727146	-	660	WP_000831301.1	membrane protein	-
EJN89_RS08735	1727206..1728348	-	1143	WP_001176871.1	glycerate kinase	-
EJN89_RS08740	1728606..1728992	+	387	WP_000779360.1	flippase GtxA	-
EJN89_RS08745	1729126..1729233	+	108	WP_000482647.1	type I toxin-antitoxin system Fst family toxin	Toxin
-	1729251..1729310	-	60	-	-	Antitoxin
EJN89_RS08755	1729917..1731680	+	1764	WP_001064816.1	ABC transporter ATP-binding protein/permease	-
EJN89_RS08760	1731705..1733438	+	1734	WP_125998338.1	ABC transporter ATP-binding protein/permease	-
EJN89_RS08770	1733669..1733836	+	168	WP_001790576.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4012.76 Da
• Isoelectric Point: 10.4935

>T116036 WP_000482647.1 NZ_CP034441:1729126-1729233 [Staphylococcus aureus]
MFNLLIDIMTSALSGCLVAFFAHWLRTRNNKKGDK

Nucleotide

• Length: 108 bp

>T116036 NZ_CP034441:1729126-1729233 [Staphylococcus aureus]
ATGTTCAATTTATTAATTGACATCATGACTTCAGCTTTAAGCGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAACAATAAAAAAGGTGACAAATAA

Antitoxin

Nucleotide

• Length: 60 bp

>AT116036 NZ_CP034441:c1729310-1729251 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGG

Structures

Toxin

• AlphaFold DB: A0A2P7CQJ7

Antitoxin