Detailed information of TA system TA116006

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/-
• Location: 3717338..3717992
• Replicon: chromosome
• Accession: NZ_CP034425
• Organism: Pseudomonas libanensis strain DMSP-1

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: EJJ21_RS17280
• Protein ID: WP_003192123.1
• Coordinates: 3717338..3717688 (+)
• Length: 117 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: A0A1T1HTP3
• Locus tag: EJJ21_RS17285
• Protein ID: WP_044274604.1
• Coordinates: 3717678..3717992 (+)
• Length: 105 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EJJ21_RS17270	3714096..3715628	+	1533	WP_014718913.1	NADH-quinone oxidoreductase subunit M	-
EJJ21_RS17275	3715636..3717099	+	1464	WP_003192122.1	NADH-quinone oxidoreductase subunit NuoN	-
EJJ21_RS17280	3717338..3717688	+	351	WP_003192123.1	toxin	Toxin
EJJ21_RS17285	3717678..3717992	+	315	WP_044274604.1	hypothetical protein	Antitoxin
EJJ21_RS17290	3718054..3718806	-	753	WP_044274605.1	outer membrane beta-barrel protein	-
EJJ21_RS17295	3718932..3719765	-	834	WP_125970321.1	arylamine N-acetyltransferase	-
EJJ21_RS17300	3719886..3720122	+	237	WP_003192128.1	hypothetical protein	-
EJJ21_RS17305	3720153..3720353	-	201	WP_032896653.1	hypothetical protein	-
EJJ21_RS17310	3720366..3720545	-	180	WP_044274608.1	hypothetical protein	-
EJJ21_RS17315	3720660..3721181	+	522	WP_044274609.1	DUF3087 domain-containing protein	-
EJJ21_RS17320	3721290..3722024	+	735	WP_044274610.1	carbonic anhydrase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 117 a.a.
• Molecular weight: 13826.71 Da
• Isoelectric Point: 9.7551

>T116006 WP_003192123.1 NZ_CP034425:3717338-3717688 [Pseudomonas libanensis]
MDALFIELPAFERHRRDYLSDELFHGFQQELMKNPEAGDVIEGTGGLRKVRFVDERRNKGKRGGLRVIYYWWSGGTQFWL
FTLYGKHEQNDLTPQHKKALKHMLDREIKARTHHET

Nucleotide

• Length: 351 bp

>T116006 NZ_CP034425:3717338-3717688 [Pseudomonas libanensis]
ATGGATGCTCTATTTATCGAACTGCCGGCATTCGAACGGCATCGCAGGGACTATCTGAGTGATGAGCTTTTTCACGGTTT
TCAGCAGGAGTTGATGAAAAACCCAGAAGCGGGAGACGTGATCGAAGGAACGGGCGGGTTGAGAAAGGTTCGGTTCGTCG
ATGAGCGACGAAACAAAGGCAAGCGCGGTGGCCTGCGGGTCATTTACTACTGGTGGTCAGGCGGTACGCAATTCTGGTTA
TTCACTTTGTACGGCAAACACGAACAGAACGACCTGACACCCCAACACAAGAAAGCCCTTAAACACATGCTAGACAGGGA
AATCAAAGCGAGAACACACCATGAAACGTGA

Antitoxin

Protein

• Length: 105 a.a.
• Molecular weight: 11783.63 Da
• Isoelectric Point: 10.9218

>AT116006 WP_044274604.1 NZ_CP034425:3717678-3717992 [Pseudomonas libanensis]
MKREIFSELVEGFDALADERQGKITLRTHKAHLNKLAPLRADEVIAVRQQLNLSRSVFAMYLRTNTRTLENWEQGRAKPN
AQAVTLIRLVARFPETVAQLAALG

Nucleotide

• Length: 315 bp

>AT116006 NZ_CP034425:3717678-3717992 [Pseudomonas libanensis]
ATGAAACGTGAAATCTTTTCCGAACTGGTCGAAGGCTTCGACGCCCTGGCCGATGAACGCCAGGGCAAAATCACCCTGCG
CACCCACAAAGCGCACCTCAACAAGCTGGCGCCACTGCGCGCTGACGAGGTAATCGCCGTACGCCAGCAACTCAACCTGT
CCCGCTCGGTATTCGCCATGTACCTGCGCACCAACACCCGCACCTTGGAGAACTGGGAGCAAGGCCGGGCCAAGCCGAAT
GCGCAGGCTGTCACGTTGATACGACTGGTGGCGCGCTTTCCGGAAACCGTGGCGCAACTTGCCGCATTGGGCTGA

Structures

Antitoxin

• AlphaFold DB: A0A1T1HTP3