Detailed information of TA system TA115828

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): ldrD-agrB/Ldr(toxin)
• Location: 4536645..4536866
• Replicon: chromosome
• Accession: NZ_CP034384
• Organism: Escherichia coli O157:H7 strain FRIK804

Toxin (Protein)

• Gene name: ldrD
• Uniprot ID: S1NWX0
• Locus tag: EJB16_RS22790
• Protein ID: WP_001295224.1
• Coordinates: 4536645..4536752 (-)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	agrB
Locus tag	-
Coordinates	4536801..4536866 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EJB16_RS22765	4531898..4532650	-	753	Protein_4446	cellulose biosynthesis protein BcsQ	-
EJB16_RS22770	4532662..4532850	-	189	WP_001063316.1	YhjR family protein	-
EJB16_RS22775	4533123..4534694	+	1572	WP_001204920.1	cellulose biosynthesis protein BcsE	-
EJB16_RS22780	4534691..4534882	+	192	WP_000988308.1	cellulose biosynthesis protein BcsF	-
EJB16_RS22785	4534879..4536558	+	1680	WP_000191596.1	cellulose biosynthesis protein BcsG	-
EJB16_RS22790	4536645..4536752	-	108	WP_001295224.1	type I toxin-antitoxin system toxin Ldr family protein	Toxin
-	4536801..4536866	+	66	NuclAT_17	-	Antitoxin
-	4536801..4536866	+	66	NuclAT_17	-	Antitoxin
-	4536801..4536866	+	66	NuclAT_17	-	Antitoxin
-	4536801..4536866	+	66	NuclAT_17	-	Antitoxin
-	4536801..4536866	+	66	NuclAT_22	-	Antitoxin
-	4536801..4536866	+	66	NuclAT_22	-	Antitoxin
-	4536801..4536866	+	66	NuclAT_22	-	Antitoxin
-	4536801..4536866	+	66	NuclAT_22	-	Antitoxin
EJB16_RS22795	4537228..4538499	+	1272	WP_001301684.1	amino acid permease	-
EJB16_RS22800	4538529..4539533	-	1005	WP_000107027.1	dipeptide ABC transporter ATP-binding subunit DppF	-
EJB16_RS22805	4539530..4540513	-	984	WP_001196486.1	dipeptide ABC transporter ATP-binding protein	-
EJB16_RS22810	4540524..4541426	-	903	WP_000084677.1	dipeptide ABC transporter permease DppC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type I toxin-antitoxin system, toxin Ldr (1-35)

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 3882.70 Da
• Isoelectric Point: 9.0157

>T115828 WP_001295224.1 NZ_CP034384:c4536752-4536645 [Escherichia coli O157:H7]
MTLAELGMAFWHDLAAPVIAGILASMIVNWLNKRK

Nucleotide

• Length: 108 bp

>T115828 NZ_CP034384:c4536752-4536645 [Escherichia coli O157:H7]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin

Nucleotide

• Length: 66 bp

>AT115828 NZ_CP034384:4536801-4536866 [Escherichia coli O157:H7]
GTCTAGGTTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Structures

Toxin

• AlphaFold DB: A0A4P7TSJ7

Antitoxin