115809

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 1550511..1551306 Replicon chromosome
Accession NZ_CP034384
Organism Escherichia coli O157:H7 strain FRIK804

Toxin (Protein)


Gene name yeeV Uniprot ID B7UP43
Locus tag EJB16_RS07465 Protein ID WP_000854914.1
Coordinates 1550932..1551306 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A0B0VS41
Locus tag EJB16_RS07460 Protein ID WP_001280954.1
Coordinates 1550511..1550885 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EJB16_RS07430 1545867..1546772 + 906 WP_000203541.1 chemotaxis protein -
EJB16_RS07435 1546769..1547839 + 1071 WP_000102669.1 patatin-like phospholipase family protein -
EJB16_RS07440 1548179..1548997 + 819 WP_001234682.1 DUF945 domain-containing protein -
EJB16_RS07445 1549087..1549572 + 486 WP_000214398.1 antirestriction protein -
EJB16_RS07450 1549588..1550064 + 477 WP_001186738.1 RadC family protein -
EJB16_RS07455 1550127..1550348 + 222 WP_001220314.1 DUF987 domain-containing protein -
EJB16_RS07460 1550511..1550885 + 375 WP_001280954.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
EJB16_RS07465 1550932..1551306 + 375 WP_000854914.1 TA system toxin CbtA family protein Toxin
EJB16_RS07470 1551303..1551794 + 492 WP_000976853.1 hypothetical protein -
EJB16_RS07475 1551806..1552003 + 198 WP_000839282.1 DUF957 domain-containing protein -
EJB16_RS07480 1552088..1552930 + 843 WP_001280481.1 DUF4942 domain-containing protein -
EJB16_RS07490 1553401..1554339 + 939 WP_000351284.1 glyoxylate/hydroxypyruvate reductase GhrA -
EJB16_RS07495 1554394..1555131 + 738 WP_000283664.1 zinc-binding phosphatase -
EJB16_RS07500 1555155..1555709 + 555 WP_001001917.1 molecular chaperone YcdY -
EJB16_RS07505 1555811..1556302 + 492 WP_001301587.1 DUF1097 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - csgG / csgF / csgE / csgD / csgB / csgA / csgC 1549588..1561870 12282


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 14117.17 Da        Isoelectric Point: 7.7761

>T115809 WP_000854914.1 NZ_CP034384:1550932-1551306 [Escherichia coli O157:H7]
MKTLSDTHVREVSRCPSPVTIWQTLLIRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T115809 NZ_CP034384:1550932-1551306 [Escherichia coli O157:H7]
ATGAAAACATTATCCGACACACATGTACGGGAGGTATCTCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAT
CCGACTGCTGGACCAGCATTATGGCCTCACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCAGTTAATTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCACCTGTCCCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCTCGCCGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 13718.51 Da        Isoelectric Point: 6.6249

>AT115809 WP_001280954.1 NZ_CP034384:1550511-1550885 [Escherichia coli O157:H7]
VSDKLSGITHPDDNHDRPWWGLPCTVRPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRYQHTVTLNAKGLTCEADTLGSCGYVYLAVYPTPAPATTS

Download         Length: 375 bp

>AT115809 NZ_CP034384:1550511-1550885 [Escherichia coli O157:H7]
GTGTCAGACAAACTCTCCGGGATAACTCATCCCGATGACAATCACGACCGCCCCTGGTGGGGGCTTCCCTGCACAGTGAG
GCCCTGTTTTGGCGCTCGTCTGGTGCAAGAGGGTAACCGCCTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGCT
TCAGCGACGCAGATGCATACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGATATCAGCATACCGTCACGCTGAATGCAAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCAGCACCCGCAACCACCTCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LXR5

Antitoxin

Source ID Structure
AlphaFold DB A0A0B0VS41

References