Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 3125427..3126052 Replicon chromosome
Accession NZ_CP034367
Organism Halomonas venusta strain MA-ZP17-13

Toxin (Protein)


Gene name graT Uniprot ID -
Locus tag EI420_RS14515 Protein ID WP_125750335.1
Coordinates 3125759..3126052 (-) Length 98 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag EI420_RS14510 Protein ID WP_125750333.1
Coordinates 3125427..3125735 (-) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EI420_RS14485 3121065..3121838 + 774 WP_125750321.1 HD domain-containing protein -
EI420_RS14490 3122019..3122429 - 411 WP_197915462.1 PaaI family thioesterase -
EI420_RS14495 3122482..3123108 - 627 WP_125750324.1 LysE family translocator -
EI420_RS14500 3123247..3124671 - 1425 WP_125750327.1 sensor domain-containing diguanylate cyclase -
EI420_RS14505 3124953..3125288 - 336 WP_125750330.1 PhnA domain-containing protein -
EI420_RS14510 3125427..3125735 - 309 WP_125750333.1 HigA family addiction module antidote protein Antitoxin
EI420_RS14515 3125759..3126052 - 294 WP_125750335.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
EI420_RS14520 3126154..3127767 - 1614 WP_125750338.1 ATP-binding cassette domain-containing protein -
EI420_RS14525 3128008..3129156 - 1149 WP_125750341.1 MFS transporter -
EI420_RS14530 3129301..3130203 + 903 WP_125750344.1 LysR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 3078315..3151197 72882


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-97)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(6-97)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 11173.83 Da        Isoelectric Point: 7.8857

>T115792 WP_125750335.1 NZ_CP034367:c3126052-3125759 [Halomonas venusta]
MIVNFKDKAVEDLFNGEHIKAARKLCPLSLWKIASRKLDLLDSAQKLDELRVPPGNRLEALSGDRARQHSIRITGQYRLC
FRWTEAGPDEVELVDYH

Download         Length: 294 bp

>T115792 NZ_CP034367:c3126052-3125759 [Halomonas venusta]
ATGATCGTAAATTTCAAAGACAAAGCGGTAGAAGACTTATTCAATGGCGAGCATATCAAGGCTGCTCGCAAGCTATGTCC
GCTATCCCTATGGAAAATTGCATCACGAAAACTCGATCTACTGGATTCGGCACAAAAGCTGGATGAACTGAGGGTACCGC
CTGGTAACCGGCTTGAAGCGTTATCAGGCGACAGAGCCAGACAGCATAGTATTCGCATCACTGGGCAGTATCGTCTCTGT
TTTAGGTGGACAGAGGCTGGGCCTGATGAGGTCGAGTTAGTCGATTACCACTAA

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 12094.93 Da        Isoelectric Point: 6.6446

>AT115792 WP_125750333.1 NZ_CP034367:c3125735-3125427 [Halomonas venusta]
MIRVPTHREPTHPGEMLLEEFLQPMDITQRELAAAIHVPYQRINELVNKKRGVTPSTALRLARFFDVSADFWLNLQMRWD
LFKAEQLEHEDLSSIQHWQKMA

Download         Length: 309 bp

>AT115792 NZ_CP034367:c3125735-3125427 [Halomonas venusta]
ATGATTCGTGTCCCCACACATCGCGAACCGACGCACCCCGGCGAAATGTTACTGGAAGAGTTTTTGCAGCCCATGGATAT
TACCCAGCGTGAGCTGGCCGCTGCTATCCACGTTCCTTACCAGCGGATCAATGAGCTGGTGAATAAAAAACGAGGTGTTA
CGCCCAGCACGGCACTAAGGCTGGCACGATTTTTTGATGTTTCAGCAGATTTTTGGCTGAATTTACAAATGCGCTGGGAT
CTCTTCAAAGCAGAGCAGTTAGAGCACGAGGATCTCTCTAGCATCCAACACTGGCAGAAGATGGCGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References