Detailed information of TA system TA115783

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/MqsA(antitoxin)
• Location: 784397..785052
• Replicon: chromosome
• Accession: NZ_CP034363
• Organism: Pantoea sp. CCBC3-3-1

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: EHV07_RS03535
• Protein ID: WP_147195125.1
• Coordinates: 784714..785052 (-)
• Length: 113 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: EHV07_RS03530
• Protein ID: WP_147195124.1
• Coordinates: 784397..784717 (-)
• Length: 107 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EHV07_RS03520	780200..783424	+	3225	WP_147195122.1	carbamoyl-phosphate synthase large subunit	-
EHV07_RS03525	783629..784363	+	735	WP_147195123.1	phosphatase PAP2 family protein	-
EHV07_RS03530	784397..784717	-	321	WP_147195124.1	type II toxin-antitoxin system MqsA family antitoxin	Antitoxin
EHV07_RS03535	784714..785052	-	339	WP_147195125.1	toxin	Toxin
EHV07_RS03540	785333..785947	-	615	WP_147195127.1	LysE family translocator	-
EHV07_RS03545	786141..786620	+	480	WP_147200514.1	type 3 dihydrofolate reductase	-
EHV07_RS03550	786653..787483	-	831	WP_147195129.1	bis(5'-nucleosyl)-tetraphosphatase (symmetrical) ApaH	-
EHV07_RS03555	787538..787915	-	378	WP_147195131.1	Co2+/Mg2+ efflux protein ApaG	-
EHV07_RS03560	787919..788746	-	828	WP_147195134.1	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))- dimethyltransferase RsmA	-
EHV07_RS03565	788739..789731	-	993	WP_147195138.1	4-hydroxythreonine-4-phosphate dehydrogenase PdxA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Cro/C1-type helix-turn-helix domain (45-88)

Sequences

Toxin

Protein

• Length: 113 a.a.
• Molecular weight: 13021.95 Da
• Isoelectric Point: 6.7166

>T115783 WP_147195125.1 NZ_CP034363:c785052-784714 [Pantoea sp. CCBC3-3-1]
VDAIFVELPPFARHRADYLSDEAFISLQNLLMLSPWCDDVIQHTGGLRKVRLGDEDRQKGKRTGLRVIYYWWQENAQFLL
FTLYSKGEMGDLTVSQKSMLRQLLDYHMAGTP

Nucleotide

• Length: 339 bp

>T115783 NZ_CP034363:c785052-784714 [Pantoea sp. CCBC3-3-1]
GTGGATGCTATCTTTGTCGAACTTCCGCCATTCGCACGCCATCGTGCGGATTATCTCTCCGATGAGGCGTTTATCAGCCT
GCAAAATCTCTTAATGCTTTCGCCATGGTGTGATGACGTTATCCAACACACGGGCGGATTGCGTAAAGTCAGGTTAGGCG
ATGAGGACCGCCAAAAAGGGAAGCGTACAGGCCTGCGGGTGATTTATTACTGGTGGCAGGAAAACGCCCAGTTCCTCCTT
TTTACGCTTTACAGTAAGGGAGAAATGGGCGATCTCACCGTCTCGCAGAAAAGCATGCTGCGTCAGTTGCTTGATTATCA
TATGGCAGGAACACCATGA

Antitoxin

Protein

• Length: 107 a.a.
• Molecular weight: 12205.19 Da
• Isoelectric Point: 10.2575

>AT115783 WP_147195124.1 NZ_CP034363:c784717-784397 [Pantoea sp. CCBC3-3-1]
MKKRQLFNELVEGMDAWGEMNAGKKTLKTHRLSVEREIVLPSSELRQIRESLQLSQALFAQYLHTGLTTYQNWEQGRAKP
NKQAILLIRMVEKDPQLLQTLAGLSL

Nucleotide

• Length: 321 bp

>AT115783 NZ_CP034363:c784717-784397 [Pantoea sp. CCBC3-3-1]
ATGAAAAAACGACAGTTGTTCAATGAGCTGGTTGAAGGGATGGATGCCTGGGGAGAGATGAATGCGGGCAAAAAAACGCT
GAAAACTCACCGGCTGAGCGTTGAACGCGAAATTGTGTTGCCCTCGTCTGAGCTACGGCAGATCAGGGAGTCGCTACAGC
TTTCGCAGGCGCTGTTTGCCCAGTACTTACATACCGGGCTGACCACCTATCAAAACTGGGAGCAGGGTCGTGCTAAACCC
AACAAGCAGGCGATTCTGCTTATCCGCATGGTTGAAAAAGATCCTCAGCTGCTGCAAACCCTTGCCGGATTGTCGCTGTA
G