Detailed information of TA system TA115782

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HigB-HigA
• Location: 640945..641673
• Replicon: chromosome
• Accession: NZ_CP034363
• Organism: Pantoea sp. CCBC3-3-1

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: EHV07_RS02885
• Protein ID: WP_147194833.1
• Coordinates: 641365..641673 (-)
• Length: 103 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: EHV07_RS02880
• Protein ID: WP_147200507.1
• Coordinates: 640945..641283 (-)
• Length: 113 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EHV07_RS02860	636255..636824	-	570	WP_147194821.1	phosphoglycerate mutase family protein	-
EHV07_RS02865	637424..638812	+	1389	WP_147194824.1	MHS family MFS transporter	-
EHV07_RS02870	638863..639891	+	1029	WP_147194827.1	LacI family transcriptional regulator	-
EHV07_RS02875	639899..640876	+	978	WP_147194830.1	nucleoside hydrolase	-
EHV07_RS02880	640945..641283	-	339	WP_147200507.1	HigA family addiction module antidote protein	Antitoxin
EHV07_RS02885	641365..641673	-	309	WP_147194833.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
EHV07_RS02890	641754..643265	-	1512	WP_147194836.1	PepSY domain-containing protein	-
EHV07_RS02895	643342..643746	-	405	WP_147200508.1	DUF2946 domain-containing protein	-
EHV07_RS02900	643971..645179	+	1209	WP_147194839.1	MFS transporter	-
EHV07_RS02905	645223..645690	-	468	WP_147194842.1	YbaK/EbsC family protein	-
EHV07_RS02910	645762..646556	-	795	WP_147194844.1	siderophore-iron reductase FhuF	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-1 (5-98)

Antitoxin

• Toxin-antitoxin system, antidote protein, HigA (1-100)

Sequences

Toxin

Protein

• Length: 103 a.a.
• Molecular weight: 12223.98 Da
• Isoelectric Point: 9.1508

>T115782 WP_147194833.1 NZ_CP034363:c641673-641365 [Pantoea sp. CCBC3-3-1]
MLRNIENFRDEWLEDYFLYGKTHKKIPANLESALARKLDLINAATTYKDLRSPPGNRYEELHPPLSEYSAIRINEQYRLI
FKWIEGKAIDLYLDPHSYKKHK

Nucleotide

• Length: 309 bp

>T115782 NZ_CP034363:c641673-641365 [Pantoea sp. CCBC3-3-1]
ATGTTGAGAAACATTGAAAATTTTAGGGATGAATGGCTTGAAGATTATTTTTTATATGGCAAAACGCATAAAAAAATCCC
GGCAAATCTGGAGTCAGCATTAGCTCGCAAACTGGACCTGATAAATGCTGCGACAACGTATAAGGACTTACGATCGCCAC
CGGGTAATCGATATGAAGAGTTGCATCCTCCGCTGAGTGAGTACTCTGCGATACGCATCAATGAGCAATACCGATTAATT
TTCAAATGGATTGAAGGAAAAGCAATTGATCTTTATTTAGATCCGCACAGTTATAAAAAACACAAATGA

Antitoxin

Protein

• Length: 113 a.a.
• Molecular weight: 12956.83 Da
• Isoelectric Point: 5.8769

>AT115782 WP_147200507.1 NZ_CP034363:c641283-640945 [Pantoea sp. CCBC3-3-1]
MKQATRKPTTPGDILLYEYLEPLSLKINDLAEMLNVHRNSVSALLNNNRKLTPDMAFRLAMVFDTSVEFWLNLQNSVDIW
EVENDARTQEEMSRVTSLERFLTQRAAKNKVA

Nucleotide

• Length: 339 bp

>AT115782 NZ_CP034363:c641283-640945 [Pantoea sp. CCBC3-3-1]
ATGAAACAAGCGACACGTAAGCCCACCACCCCAGGCGATATTTTGTTATACGAATACCTGGAACCGCTTTCGCTAAAAAT
CAATGACTTAGCAGAGATGCTCAATGTACACCGTAATTCGGTCAGCGCTTTACTGAATAACAACCGCAAACTGACGCCTG
ATATGGCTTTCAGACTGGCTATGGTCTTTGATACCAGCGTTGAATTTTGGTTAAACCTGCAAAACAGCGTGGATATTTGG
GAAGTGGAAAACGATGCGCGCACTCAGGAAGAGATGAGCCGCGTAACCTCTTTAGAACGTTTTCTTACGCAGCGAGCCGC
TAAGAACAAGGTAGCCTGA