Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 640945..641673 Replicon chromosome
Accession NZ_CP034363
Organism Pantoea sp. CCBC3-3-1

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag EHV07_RS02885 Protein ID WP_147194833.1
Coordinates 641365..641673 (-) Length 103 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag EHV07_RS02880 Protein ID WP_147200507.1
Coordinates 640945..641283 (-) Length 113 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EHV07_RS02860 636255..636824 - 570 WP_147194821.1 phosphoglycerate mutase family protein -
EHV07_RS02865 637424..638812 + 1389 WP_147194824.1 MHS family MFS transporter -
EHV07_RS02870 638863..639891 + 1029 WP_147194827.1 LacI family transcriptional regulator -
EHV07_RS02875 639899..640876 + 978 WP_147194830.1 nucleoside hydrolase -
EHV07_RS02880 640945..641283 - 339 WP_147200507.1 HigA family addiction module antidote protein Antitoxin
EHV07_RS02885 641365..641673 - 309 WP_147194833.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
EHV07_RS02890 641754..643265 - 1512 WP_147194836.1 PepSY domain-containing protein -
EHV07_RS02895 643342..643746 - 405 WP_147200508.1 DUF2946 domain-containing protein -
EHV07_RS02900 643971..645179 + 1209 WP_147194839.1 MFS transporter -
EHV07_RS02905 645223..645690 - 468 WP_147194842.1 YbaK/EbsC family protein -
EHV07_RS02910 645762..646556 - 795 WP_147194844.1 siderophore-iron reductase FhuF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(5-98)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-100)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 12223.98 Da        Isoelectric Point: 9.1508

>T115782 WP_147194833.1 NZ_CP034363:c641673-641365 [Pantoea sp. CCBC3-3-1]
MLRNIENFRDEWLEDYFLYGKTHKKIPANLESALARKLDLINAATTYKDLRSPPGNRYEELHPPLSEYSAIRINEQYRLI
FKWIEGKAIDLYLDPHSYKKHK

Download         Length: 309 bp

>T115782 NZ_CP034363:c641673-641365 [Pantoea sp. CCBC3-3-1]
ATGTTGAGAAACATTGAAAATTTTAGGGATGAATGGCTTGAAGATTATTTTTTATATGGCAAAACGCATAAAAAAATCCC
GGCAAATCTGGAGTCAGCATTAGCTCGCAAACTGGACCTGATAAATGCTGCGACAACGTATAAGGACTTACGATCGCCAC
CGGGTAATCGATATGAAGAGTTGCATCCTCCGCTGAGTGAGTACTCTGCGATACGCATCAATGAGCAATACCGATTAATT
TTCAAATGGATTGAAGGAAAAGCAATTGATCTTTATTTAGATCCGCACAGTTATAAAAAACACAAATGA

Antitoxin


Download         Length: 113 a.a.        Molecular weight: 12956.83 Da        Isoelectric Point: 5.8769

>AT115782 WP_147200507.1 NZ_CP034363:c641283-640945 [Pantoea sp. CCBC3-3-1]
MKQATRKPTTPGDILLYEYLEPLSLKINDLAEMLNVHRNSVSALLNNNRKLTPDMAFRLAMVFDTSVEFWLNLQNSVDIW
EVENDARTQEEMSRVTSLERFLTQRAAKNKVA

Download         Length: 339 bp

>AT115782 NZ_CP034363:c641283-640945 [Pantoea sp. CCBC3-3-1]
ATGAAACAAGCGACACGTAAGCCCACCACCCCAGGCGATATTTTGTTATACGAATACCTGGAACCGCTTTCGCTAAAAAT
CAATGACTTAGCAGAGATGCTCAATGTACACCGTAATTCGGTCAGCGCTTTACTGAATAACAACCGCAAACTGACGCCTG
ATATGGCTTTCAGACTGGCTATGGTCTTTGATACCAGCGTTGAATTTTGGTTAAACCTGCAAAACAGCGTGGATATTTGG
GAAGTGGAAAACGATGCGCGCACTCAGGAAGAGATGAGCCGCGTAACCTCTTTAGAACGTTTTCTTACGCAGCGAGCCGC
TAAGAACAAGGTAGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References