Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2419953..2420476 Replicon chromosome
Accession NZ_CP034349
Organism Staphylococcus aureus strain 80wphwpl

Toxin (Protein)


Gene name yoeB Uniprot ID A0A2W3LFI1
Locus tag C6567_RS12270 Protein ID WP_000074047.1
Coordinates 2419953..2420219 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A2S6D1W5
Locus tag C6567_RS12275 Protein ID WP_000587617.1
Coordinates 2420219..2420476 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C6567_RS12250 2415163..2416350 - 1188 WP_000026190.1 MFS transporter -
C6567_RS12255 2416744..2417520 - 777 WP_000072154.1 iron export ABC transporter permease subunit FetB -
C6567_RS12260 2417513..2418175 - 663 WP_000923514.1 ATP-binding cassette domain-containing protein -
C6567_RS12265 2418521..2419597 - 1077 WP_001076679.1 M42 family metallopeptidase -
C6567_RS12270 2419953..2420219 - 267 WP_000074047.1 Txe/YoeB family addiction module toxin Toxin
C6567_RS12275 2420219..2420476 - 258 WP_000587617.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
C6567_RS12285 2420836..2421291 + 456 WP_000732090.1 YehR family lipoprotein -
C6567_RS12290 2421459..2423036 - 1578 WP_124733838.1 FMN-binding glutamate synthase family protein -
C6567_RS12295 2423232..2423981 + 750 WP_000072447.1 CPBP family intramembrane metalloprotease -
C6567_RS12300 2424205..2425398 - 1194 WP_000675407.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(4-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10662.26 Da        Isoelectric Point: 10.1384

>T115770 WP_000074047.1 NZ_CP034349:c2420219-2419953 [Staphylococcus aureus]
MSNYTVKIKNSAKSDLKKIKHSYLKKSFLEIVETLKNDPYKITQSFEKLEPKYLERYSRRINHQHRIVYTVDDRNKEVLI
LSAWSHYD

Download         Length: 267 bp

>T115770 NZ_CP034349:c2420219-2419953 [Staphylococcus aureus]
ATGAGCAATTACACGGTTAAGATTAAAAATTCAGCGAAATCAGATTTAAAGAAAATAAAACATTCTTATTTAAAGAAGTC
ATTTTTAGAAATTGTTGAGACTTTAAAAAATGATCCGTATAAAATAACACAATCCTTTGAAAAATTAGAACCTAAATATT
TAGAGCGATATTCAAGAAGAATTAACCATCAGCACAGGATCGTCTATACCGTAGATGATCGAAATAAAGAAGTATTAATA
CTATCGGCATGGTCACATTATGATTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9747.71 Da        Isoelectric Point: 4.1353

>AT115770 WP_000587617.1 NZ_CP034349:c2420476-2420219 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETIYLESTGTMDKVREREKDSSGTTNIDDI
DWDNL

Download         Length: 258 bp

>AT115770 NZ_CP034349:c2420476-2420219 [Staphylococcus aureus]
ATGATTATCACTAGCCCTACAGAAGCGAGAAAAGATTTTTATCAATTACTAAAAAATGTTAATAATAATCACGAACCAAT
TTATATTAGTGGCAATAATGCCGAAAATAATGCTGTGATTATAGGTTTAGAAGATTGGAAAAGTATACAAGAGACAATAT
ATCTTGAATCTACTGGTACAATGGACAAAGTAAGAGAAAGAGAAAAAGATAGTAGTGGTACAACAAATATAGATGATATT
GATTGGGATAATCTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2W3LFI1

Antitoxin

Source ID Structure
AlphaFold DB A0A2S6D1W5

References