Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-HTH
Location 1161427..1162031 Replicon chromosome
Accession NZ_CP034338
Organism Pseudomonas entomophila strain 1257

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag EJA05_RS05510 Protein ID WP_125462793.1
Coordinates 1161711..1162031 (-) Length 107 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag EJA05_RS05505 Protein ID WP_125462792.1
Coordinates 1161427..1161714 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EJA05_RS05480 1157405..1158013 + 609 WP_125462787.1 hypothetical protein -
EJA05_RS05485 1158113..1159333 + 1221 WP_125857590.1 SAM-dependent methyltransferase -
EJA05_RS05495 1159777..1160286 + 510 WP_125857591.1 DNA-binding protein -
EJA05_RS05500 1160309..1161319 - 1011 WP_125857592.1 DUF4917 family protein -
EJA05_RS05505 1161427..1161714 - 288 WP_125462792.1 helix-turn-helix domain-containing protein Antitoxin
EJA05_RS05510 1161711..1162031 - 321 WP_125462793.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
EJA05_RS05515 1162163..1163863 - 1701 WP_125857593.1 SulP family inorganic anion transporter -
EJA05_RS05525 1164255..1165139 - 885 WP_125462795.1 alpha/beta hydrolase -
EJA05_RS05530 1165587..1166279 - 693 WP_125857594.1 16S rRNA pseudouridine(516) synthase -
EJA05_RS05535 1166311..1166532 - 222 WP_125462797.1 cysteine-rich CWC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(43-99)

Antitoxin

Cro/C1-type helix-turn-helix domain

(35-87)


Sequences

Toxin        


Download         Length: 107 a.a.        Molecular weight: 12091.90 Da        Isoelectric Point: 10.1563

>T115751 WP_125462793.1 NZ_CP034338:c1162031-1161711 [Pseudomonas entomophila]
MLFTETAVFTKRAKELLDDETYRLLQVRLLISPDAGDVIEGTGGLRKIRAPANGHGKRGGARVIYYHFTARSHITLLYIF
AKNEQTELSAEQRKALKSVIENWRYP

Download         Length: 321 bp

>T115751 NZ_CP034338:c1162031-1161711 [Pseudomonas entomophila]
ATGCTTTTTACCGAAACCGCTGTCTTTACCAAGCGCGCAAAAGAGCTGCTCGACGACGAAACCTACAGGTTGTTGCAGGT
TCGTCTTTTGATATCCCCCGATGCAGGGGATGTCATCGAAGGGACCGGCGGCCTGCGCAAAATCCGCGCCCCAGCGAACG
GCCACGGCAAGCGAGGCGGCGCCAGAGTCATCTACTACCACTTCACGGCAAGGTCACATATCACCTTGCTCTACATCTTT
GCGAAGAACGAACAAACGGAGCTATCCGCCGAACAGCGCAAGGCTTTGAAGTCCGTCATCGAAAACTGGAGATACCCATG
A

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10949.55 Da        Isoelectric Point: 6.7284

>AT115751 WP_125462792.1 NZ_CP034338:c1161714-1161427 [Pseudomonas entomophila]
MSRLFDELMESVVEMDEIIQGKRQPSRQFEIDALQVREIRKATGLSQVRFAEMIDVQVATLRNWEQGRREPTGPAKALLR
AIHNDPDHVLKALSH

Download         Length: 288 bp

>AT115751 NZ_CP034338:c1161714-1161427 [Pseudomonas entomophila]
ATGAGCCGCCTCTTCGACGAACTGATGGAAAGCGTTGTAGAAATGGATGAAATCATCCAGGGCAAACGCCAACCCTCGCG
CCAGTTCGAAATCGACGCCCTTCAAGTCCGGGAAATCCGTAAGGCCACCGGTTTGTCACAGGTACGTTTCGCCGAGATGA
TCGATGTGCAAGTCGCTACGCTGCGTAACTGGGAACAGGGGCGCCGGGAGCCCACGGGGCCTGCCAAGGCGCTGCTGCGG
GCCATCCACAACGACCCTGATCACGTGCTCAAGGCCTTGTCGCATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References