Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-HTH
Location 1100132..1100736 Replicon chromosome
Accession NZ_CP034337
Organism Pseudomonas entomophila strain 2014

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag EI693_RS05285 Protein ID WP_125462793.1
Coordinates 1100416..1100736 (-) Length 107 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag EI693_RS05280 Protein ID WP_125462792.1
Coordinates 1100132..1100419 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EI693_RS05255 1096110..1096718 + 609 WP_125462787.1 hypothetical protein -
EI693_RS05260 1096818..1098038 + 1221 WP_125462788.1 SAM-dependent methyltransferase -
EI693_RS05270 1098482..1098991 + 510 WP_125462790.1 DNA-binding protein -
EI693_RS05275 1099014..1100024 - 1011 WP_125462791.1 DUF4917 family protein -
EI693_RS05280 1100132..1100419 - 288 WP_125462792.1 helix-turn-helix domain-containing protein Antitoxin
EI693_RS05285 1100416..1100736 - 321 WP_125462793.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
EI693_RS05290 1100868..1102568 - 1701 WP_125462794.1 SulP family inorganic anion transporter -
EI693_RS05300 1102960..1103844 - 885 WP_125462795.1 alpha/beta hydrolase -
EI693_RS05305 1104292..1104984 - 693 WP_125462796.1 16S rRNA pseudouridine(516) synthase -
EI693_RS05310 1105016..1105237 - 222 WP_125462797.1 cysteine-rich CWC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(43-99)

Antitoxin

Cro/C1-type helix-turn-helix domain

(35-87)


Sequences

Toxin        


Download         Length: 107 a.a.        Molecular weight: 12091.90 Da        Isoelectric Point: 10.1563

>T115743 WP_125462793.1 NZ_CP034337:c1100736-1100416 [Pseudomonas entomophila]
MLFTETAVFTKRAKELLDDETYRLLQVRLLISPDAGDVIEGTGGLRKIRAPANGHGKRGGARVIYYHFTARSHITLLYIF
AKNEQTELSAEQRKALKSVIENWRYP

Download         Length: 321 bp

>T115743 NZ_CP034337:c1100736-1100416 [Pseudomonas entomophila]
ATGCTTTTTACCGAAACCGCTGTCTTTACCAAGCGCGCAAAAGAGCTGCTCGACGACGAAACCTACAGGTTGTTGCAGGT
TCGTCTTTTGATATCCCCCGATGCAGGGGATGTCATCGAAGGGACCGGCGGCCTGCGCAAAATCCGCGCCCCAGCGAATG
GCCACGGCAAGCGAGGCGGCGCCAGAGTCATCTACTACCACTTCACGGCAAGGTCACATATCACCTTGCTCTACATCTTT
GCGAAGAACGAACAAACGGAGCTATCCGCCGAACAGCGCAAGGCTTTGAAGTCCGTCATCGAAAACTGGAGATACCCATG
A

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10949.55 Da        Isoelectric Point: 6.7284

>AT115743 WP_125462792.1 NZ_CP034337:c1100419-1100132 [Pseudomonas entomophila]
MSRLFDELMESVVEMDEIIQGKRQPSRQFEIDALQVREIRKATGLSQVRFAEMIDVQVATLRNWEQGRREPTGPAKALLR
AIHNDPDHVLKALSH

Download         Length: 288 bp

>AT115743 NZ_CP034337:c1100419-1100132 [Pseudomonas entomophila]
ATGAGCCGCCTCTTCGACGAACTGATGGAAAGCGTTGTAGAAATGGATGAAATCATCCAGGGCAAACGCCAACCCTCGCG
CCAGTTCGAAATCGACGCCCTTCAAGTCCGGGAAATCCGTAAGGCCACCGGTTTGTCACAGGTACGTTTCGCCGAGATGA
TCGATGTGCAAGTCGCTACGCTGCGTAACTGGGAACAGGGGCGCCGGGAGCCCACGGGGCCTGCCAAAGCGCTGCTGCGG
GCCATCCACAACGACCCTGATCACGTGCTCAAGGCCTTGTCGCATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References