Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 4489339..4489999 Replicon chromosome
Accession NZ_CP034336
Organism Enterobacter asburiae strain CAV1043

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag EI562_RS22305 Protein ID WP_023312343.1
Coordinates 4489339..4489692 (+) Length 118 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag EI562_RS22310 Protein ID WP_023312342.1
Coordinates 4489697..4489999 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EI562_RS22285 4485481..4486398 + 918 WP_008499475.1 nitrogen assimilation transcriptional regulator NAC -
EI562_RS22290 4486495..4487445 + 951 WP_010432106.1 HTH-type transcriptional regulator Cbl -
EI562_RS22295 4487489..4488097 - 609 WP_057060296.1 glutathione S-transferase family protein -
EI562_RS22300 4488268..4489161 + 894 WP_023312344.1 LysR family transcriptional regulator -
EI562_RS22305 4489339..4489692 + 354 WP_023312343.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
EI562_RS22310 4489697..4489999 + 303 WP_023312342.1 XRE family transcriptional regulator Antitoxin
EI562_RS22315 4490075..4490995 - 921 WP_023312341.1 LysR family transcriptional regulator -
EI562_RS22320 4491137..4491526 + 390 WP_023312340.1 RidA family protein -
EI562_RS22330 4491850..4494039 - 2190 WP_023312339.1 TonB-dependent siderophore receptor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-106)

Antitoxin

Cro/C1-type helix-turn-helix domain

(33-79)


Sequences

Toxin        


Download         Length: 118 a.a.        Molecular weight: 13545.39 Da        Isoelectric Point: 9.0310

>T115733 WP_023312343.1 NZ_CP034336:4489339-4489692 [Enterobacter asburiae]
VWAINTTDRFDRWFTSLEDTERASVLAALLVLREKGPGLSRPYADTLKGSRHSNMKELRIQSKGDPLRAFFAFDPNRTGI
VLCAGNKVGNERRFYDEMLLVADREFTHWLNTLKERE

Download         Length: 354 bp

>T115733 NZ_CP034336:4489339-4489692 [Enterobacter asburiae]
GTGTGGGCAATTAACACGACGGACAGGTTTGATCGCTGGTTTACTTCGCTTGAAGATACCGAACGCGCCAGCGTACTTGC
AGCCCTGCTTGTTTTGCGAGAGAAGGGGCCGGGTTTATCGAGACCCTACGCCGATACGCTTAAAGGCTCTCGTCACAGCA
ACATGAAAGAGCTACGTATTCAGAGTAAGGGCGATCCCTTGCGGGCGTTTTTCGCCTTTGATCCAAACCGCACGGGTATC
GTGCTTTGTGCGGGCAATAAGGTCGGCAATGAAAGGCGATTCTACGATGAGATGCTTCTCGTTGCTGACCGGGAATTCAC
TCACTGGCTGAATACATTAAAAGAGAGGGAATAG

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11049.85 Da        Isoelectric Point: 6.4720

>AT115733 WP_023312342.1 NZ_CP034336:4489697-4489999 [Enterobacter asburiae]
MGRTLEQLIANEKPEVVASAQAIATDILLNIHLAELREKVQKTQVEMAQALGIRQPTVAVMEKPGRDLKLSSLKRYVEAA
GGKLRLDVELPDGSHYEFVL

Download         Length: 303 bp

>AT115733 NZ_CP034336:4489697-4489999 [Enterobacter asburiae]
ATGGGAAGAACCCTTGAGCAGCTTATAGCGAATGAAAAGCCGGAGGTTGTCGCCAGCGCTCAGGCGATAGCAACGGATAT
TTTGCTCAACATTCATCTTGCTGAGTTACGCGAGAAAGTACAAAAAACGCAGGTAGAAATGGCGCAGGCGTTGGGTATCA
GGCAACCTACCGTTGCGGTAATGGAAAAGCCCGGGCGCGATTTGAAACTCTCTTCTCTCAAGCGCTACGTTGAGGCGGCG
GGCGGAAAGCTGCGGCTTGATGTGGAGCTGCCGGATGGCTCGCACTATGAGTTCGTGCTGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References