Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 444909..445633 Replicon chromosome
Accession NZ_CP034276
Organism Pectobacterium versatile strain 14A

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag EIP93_RS02040 Protein ID WP_095993506.1
Coordinates 444909..445220 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag EIP93_RS02045 Protein ID WP_125232192.1
Coordinates 445217..445633 (+) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EIP93_RS02020 440861..442396 - 1536 WP_116362402.1 carbohydrate porin -
EIP93_RS02025 442595..443518 - 924 WP_125232190.1 aminoimidazole riboside kinase -
EIP93_RS02030 443842..444030 + 189 WP_039555433.1 hypothetical protein -
EIP93_RS02035 444200..444751 + 552 WP_125232191.1 polymer-forming cytoskeletal protein -
EIP93_RS02040 444909..445220 + 312 WP_095993506.1 type II toxin-antitoxin system HigB family toxin Toxin
EIP93_RS02045 445217..445633 + 417 WP_125232192.1 helix-turn-helix domain-containing protein Antitoxin
EIP93_RS02050 445841..446299 + 459 WP_039470406.1 hypothetical protein -
EIP93_RS02055 446397..447749 - 1353 WP_125232193.1 aspartate aminotransferase family protein -
EIP93_RS02060 447801..449057 - 1257 WP_125232194.1 MFS transporter -
EIP93_RS02065 449211..449657 + 447 WP_040031897.1 helix-turn-helix transcriptional regulator -
EIP93_RS02070 449667..450134 + 468 WP_125232195.1 YhbP family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(20-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(83-136)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12436.31 Da        Isoelectric Point: 10.0380

>T115642 WP_095993506.1 NZ_CP034276:444909-445220 [Pectobacterium versatile]
MHVISRAPFDTATTQFPNQATALADLYRVIKREMYATPDDMKKRFPSLDRMKYREKWWVIDIGGGHLRVMFFADFERGKI
FIKHITSHAEYDRLTEYYRRNKE

Download         Length: 312 bp

>T115642 NZ_CP034276:444909-445220 [Pectobacterium versatile]
ATGCATGTTATTTCGCGGGCACCTTTCGACACTGCAACCACTCAGTTTCCGAATCAGGCTACAGCACTTGCTGACCTATA
TCGGGTTATCAAACGCGAAATGTATGCAACACCGGACGATATGAAAAAACGTTTCCCTAGCCTAGATAGGATGAAATACC
GGGAAAAATGGTGGGTTATTGATATTGGTGGCGGGCATCTTCGAGTGATGTTTTTTGCTGATTTTGAGCGGGGGAAAATC
TTCATCAAGCACATTACATCCCATGCAGAGTATGACAGGCTGACAGAGTATTACCGGAGGAATAAAGAATGA

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15421.72 Da        Isoelectric Point: 4.6581

>AT115642 WP_125232192.1 NZ_CP034276:445217-445633 [Pectobacterium versatile]
MMYADAIKAANNLTSIVPFLGGSTSRKDYEDALKLTEYLIESEPDSPLIDMLTAKIDKYENDAPEFAAFNERVKALPAGI
ALLRVLMDQHQLMQSDFEAEIGKKSLVSRILNGERTLTLDHMRALAKRFDIPVSAFVD

Download         Length: 417 bp

>AT115642 NZ_CP034276:445217-445633 [Pectobacterium versatile]
ATGATGTACGCAGACGCTATCAAGGCAGCTAACAACCTGACGAGTATCGTACCATTCCTCGGAGGCAGCACCTCTCGTAA
GGATTATGAGGATGCGCTGAAACTCACTGAATACCTGATCGAGAGTGAGCCTGATAGTCCGCTAATCGATATGCTGACTG
CCAAAATTGACAAATACGAGAATGATGCACCGGAGTTTGCAGCCTTCAACGAACGTGTTAAAGCACTCCCGGCCGGTATC
GCTTTACTGCGCGTCCTTATGGATCAGCATCAGCTAATGCAGAGTGATTTTGAAGCTGAGATTGGTAAAAAGTCTCTGGT
ATCCCGCATTCTAAACGGTGAGCGCACTCTAACGCTTGATCACATGAGAGCGCTTGCTAAACGATTCGATATTCCCGTGA
GTGCTTTTGTTGATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References