115634

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) SprA2-SprA2AS/-
Location 2504339..2504523 Replicon chromosome
Accession NZ_CP034259
Organism Staphylococcus aureus strain P1D12C1

Toxin (Protein)


Gene name SprA2 Uniprot ID A0A2U0ISP5
Locus tag EFD74_RS12535 Protein ID WP_000482652.1
Coordinates 2504416..2504523 (-) Length 36 a.a.

Antitoxin (RNA)


Gene name SprA2AS
Locus tag -
Coordinates 2504339..2504399 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EFD74_RS12520 2499794..2499961 - 168 Protein_2401 hypothetical protein -
EFD74_RS12525 2500192..2501925 - 1734 WP_000486487.1 ABC transporter ATP-binding protein/permease -
EFD74_RS12530 2501950..2503713 - 1764 WP_001064825.1 ABC transporter ATP-binding protein/permease -
- 2504339..2504399 + 61 - - Antitoxin
EFD74_RS12535 2504416..2504523 - 108 WP_000482652.1 type I toxin-antitoxin system Fst family toxin Toxin
EFD74_RS12540 2504657..2505043 - 387 WP_000779360.1 flippase GtxA -
EFD74_RS12545 2505311..2506453 + 1143 WP_001176863.1 glycerate kinase -
EFD74_RS12550 2506513..2507172 + 660 WP_000831298.1 membrane protein -
EFD74_RS12555 2507354..2508565 + 1212 WP_156668050.1 multidrug effflux MFS transporter -
EFD74_RS12560 2508688..2509161 - 474 WP_000456486.1 GyrI-like domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 4011.78 Da        Isoelectric Point: 11.0582

>T115634 WP_000482652.1 NZ_CP034259:c2504523-2504416 [Staphylococcus aureus]
MFNLLINIMTSALSGCLVAFFAHWLRTRNNKKGDK

Download         Length: 108 bp

>T115634 NZ_CP034259:c2504523-2504416 [Staphylococcus aureus]
ATGTTCAATTTATTAATTAACATCATGACTTCAGCTTTAAGCGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAACAATAAAAAAGGTGACAAATAA

Antitoxin


Download         Length: 61 bp

>AT115634 NZ_CP034259:2504339-2504399 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2U0ISP5

Antitoxin

Download structure file

References