Detailed information of TA system TA115620

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): TMCS/-
• Location: 1556783..1557362
• Replicon: chromosome
• Accession: NZ_CP034259
• Organism: Staphylococcus aureus strain P1D12C1

Toxin (Protein)

• Gene name: MW1434
• Uniprot ID: A0A4P7P609
• Locus tag: EFD74_RS07440
• Protein ID: WP_001025401.1
• Coordinates: 1557117..1557362 (-)
• Length: 82 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	1556783..1557148 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EFD74_RS07400	1553525..1554082	-	558	WP_000645042.1	DUF2815 family protein	-
EFD74_RS07405	1554109..1555275	-	1167	WP_000762527.1	DUF2800 domain-containing protein	-
EFD74_RS07410	1555272..1555634	-	363	WP_000985972.1	hypothetical protein	-
EFD74_RS07415	1555649..1555972	-	324	WP_000174998.1	hypothetical protein	-
EFD74_RS07420	1556051..1556212	-	162	WP_001285954.1	DUF1270 domain-containing protein	-
EFD74_RS07425	1556225..1556488	-	264	WP_001124160.1	helix-turn-helix domain-containing protein	-
EFD74_RS07430	1556513..1556728	-	216	WP_001097552.1	hypothetical protein	-
EFD74_RS07435	1556783..1557148	+	366	WP_001128433.1	hypothetical protein	Antitoxin
EFD74_RS07440	1557117..1557362	-	246	WP_001025401.1	DUF2829 domain-containing protein	Toxin
EFD74_RS07445	1557429..1557809	+	381	WP_000773059.1	DUF2513 domain-containing protein	-
EFD74_RS07450	1557796..1557993	-	198	WP_001148860.1	hypothetical protein	-
EFD74_RS07455	1558063..1558275	+	213	WP_000362644.1	hypothetical protein	-
EFD74_RS14035	1558316..1558465	-	150	WP_000771849.1	hypothetical protein	-
EFD74_RS07460	1558480..1558923	-	444	WP_000435357.1	hypothetical protein	-
EFD74_RS07465	1558971..1559183	-	213	WP_000213811.1	helix-turn-helix transcriptional regulator	-
EFD74_RS07470	1559335..1560066	+	732	WP_000511090.1	XRE family transcriptional regulator	-
EFD74_RS07475	1560136..1560318	+	183	WP_000705240.1	hypothetical protein	-
EFD74_RS07480	1560354..1560500	+	147	WP_001795334.1	hypothetical protein	-
EFD74_RS07485	1560497..1561111	-	615	WP_000191466.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1514337..1580067	65730

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF2829 (2-69)

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 9468.72 Da
• Isoelectric Point: 5.7783

>T115620 WP_001025401.1 NZ_CP034259:c1557362-1557117 [Staphylococcus aureus]
MNIQEATKIATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISNSDGTNLIRYWQPSADDLMANDWEVINPTRDQELLKQ
F

Nucleotide

• Length: 246 bp

>T115620 NZ_CP034259:c1557362-1557117 [Staphylococcus aureus]
ATGAACATTCAAGAAGCAACTAAGATAGCTACAAAAAATCTTGTCTCTATGACACGGAAAGATTGGAAAGAAAGTCATCG
AACTAAGATATTACCAACAAATGATAGTTTTTTACAATGCATCATTTCAAATAGCGATGGGACAAACCTTATCAGATATT
GGCAACCTTCAGCCGATGACCTCATGGCAAATGATTGGGAAGTTATAAACCCAACTAGAGACCAGGAATTATTGAAGCAA
TTTTAG

Antitoxin

Nucleotide

• Length: 366 bp

>AT115620 NZ_CP034259:1556783-1557148 [Staphylococcus aureus]
ATGCCCTTGATATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTCCGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGGTTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTCGAAGATGTAAAATACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTAAAATTGCTTCAATAATTCCTGGTCTCTAG

Structures

Toxin

• AlphaFold DB: A0A4P7P609

Antitoxin