Detailed information of TA system TA115536

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/YoeB-RelB
• Location: 176667..177172
• Replicon: chromosome
• Accession: NZ_CP034225
• Organism: Kosakonia sp. CCTCC M2018092

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: EH164_RS00850
• Protein ID: WP_054802690.1
• Coordinates: 176912..177172 (+)
• Length: 87 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: -
• Locus tag: EH164_RS00845
• Protein ID: WP_054802741.1
• Coordinates: 176667..176915 (+)
• Length: 83 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EH164_RS00825	173164..173610	-	447	WP_124967031.1	N-acetyltransferase	-
EH164_RS00830	173588..174169	-	582	WP_124971202.1	DNA-3-methyladenine glycosylase I	-
EH164_RS00835	174317..174997	+	681	WP_094418958.1	autotransporter domain-containing protein	-
EH164_RS00840	175239..176441	+	1203	WP_076769346.1	MFS transporter	-
EH164_RS00845	176667..176915	+	249	WP_054802741.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
EH164_RS00850	176912..177172	+	261	WP_054802690.1	Txe/YoeB family addiction module toxin	Toxin
EH164_RS00855	177276..177707	+	432	WP_124967032.1	organic hydroperoxide resistance protein	-
EH164_RS00860	177922..179604	+	1683	WP_124967033.1	kdo(2)-lipid A phosphoethanolamine 7''-transferase	-
EH164_RS00870	180560..182167	+	1608	WP_042713259.1	ABC transporter substrate-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (6-83)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-74)

Sequences

Toxin

Protein

• Length: 87 a.a.
• Molecular weight: 10250.87 Da
• Isoelectric Point: 9.7713

>T115536 WP_054802690.1 NZ_CP034225:176912-177172 [Kosakonia sp. CCTCC M2018092]
MTPRITPEAQADIDFWKQNDPKVKQKIDTLVRDALEHPFQGLGKPEALKHHKPLWSRRITKEHRLVYYIKDDSLIIVSCR
YHYVNL

Nucleotide

• Length: 261 bp

>T115536 NZ_CP034225:176912-177172 [Kosakonia sp. CCTCC M2018092]
ATGACGCCCAGGATAACGCCGGAAGCACAAGCTGATATAGATTTCTGGAAGCAGAACGACCCTAAGGTAAAGCAGAAAAT
TGATACCCTCGTCAGGGATGCGCTTGAGCACCCTTTCCAGGGGCTCGGAAAGCCGGAGGCGCTCAAGCACCATAAGCCGC
TCTGGTCGCGCCGCATCACCAAAGAGCATCGTCTCGTTTACTACATAAAAGATGACTCGCTGATTATCGTTTCTTGCCGC
TACCACTACGTAAATCTTTAA

Antitoxin

Protein

• Length: 83 a.a.
• Molecular weight: 9217.28 Da
• Isoelectric Point: 4.5298

>AT115536 WP_054802741.1 NZ_CP034225:176667-176915 [Kosakonia sp. CCTCC M2018092]
MQHVNYTDARQNLASLMQQANDELAPILVTRKGAKSVVVIDAEEFASMQETLHLFSNPVNAAHIERSIQQAESGDLQEYK
FE

Nucleotide

• Length: 249 bp

>AT115536 NZ_CP034225:176667-176915 [Kosakonia sp. CCTCC M2018092]
ATGCAACATGTTAACTACACTGACGCCCGCCAGAACCTGGCTTCGCTGATGCAGCAGGCAAATGACGAGCTGGCACCGAT
CCTTGTCACCCGCAAAGGGGCTAAAAGCGTGGTGGTTATCGATGCCGAGGAGTTTGCCTCTATGCAAGAGACGCTTCATC
TGTTCAGCAACCCGGTCAACGCTGCGCATATTGAGCGCAGCATCCAACAGGCGGAAAGCGGCGACCTACAGGAATATAAA
TTTGAATGA