Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 49315..50022 Replicon chromosome
Accession NZ_CP034225
Organism Kosakonia sp. CCTCC M2018092

Toxin (Protein)


Gene name mqsR Uniprot ID -
Locus tag EH164_RS00250 Protein ID WP_124966952.1
Coordinates 49717..50022 (-) Length 102 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID -
Locus tag EH164_RS00245 Protein ID WP_124966951.1
Coordinates 49315..49716 (-) Length 134 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EH164_RS00225 45091..46038 + 948 WP_042715135.1 ABC transporter permease -
EH164_RS00230 46035..47018 + 984 WP_042715059.1 ABC transporter ATP-binding protein -
EH164_RS00235 47015..47989 + 975 WP_124966950.1 ATP-binding cassette domain-containing protein -
EH164_RS00240 48063..49256 + 1194 WP_042715056.1 glutathione-dependent formaldehyde dehydrogenase -
EH164_RS00245 49315..49716 - 402 WP_124966951.1 type II toxin-antitoxin system MqsA family antitoxin Antitoxin
EH164_RS00250 49717..50022 - 306 WP_124966952.1 type II toxin-antitoxin system MqsR family toxin Toxin
EH164_RS00255 50180..50833 - 654 WP_124966953.1 oxygen-insensitive NAD(P)H nitroreductase -
EH164_RS00260 51028..51963 + 936 WP_124971187.1 LysR family transcriptional regulator -
EH164_RS00265 52025..52978 + 954 WP_124966954.1 aldo/keto reductase -
EH164_RS00270 53101..54039 + 939 WP_124966955.1 peptidoglycan-binding protein -
EH164_RS00275 54036..54464 + 429 WP_124966956.1 DUF1311 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-100)

Antitoxin

Cro/C1-type helix-turn-helix domain

(74-127)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 11560.57 Da        Isoelectric Point: 8.9492

>T115535 WP_124966952.1 NZ_CP034225:c50022-49717 [Kosakonia sp. CCTCC M2018092]
MEKGTPHVRLHIVKRMVLEGKVRTTASAVAGAIELGFNPPPFDEMCAVILALTSEDFFKSMTAYADHTVWHDVYRPVWKR
QKLYLKLIVSDDVLIVSFKER

Download         Length: 306 bp

>T115535 NZ_CP034225:c50022-49717 [Kosakonia sp. CCTCC M2018092]
ATGGAGAAAGGAACTCCCCATGTCCGCTTACATATCGTGAAGCGGATGGTGCTCGAGGGAAAGGTTAGAACCACAGCCAG
CGCTGTCGCGGGAGCGATTGAATTGGGCTTTAATCCACCGCCATTTGACGAGATGTGCGCGGTGATTCTGGCGCTCACTT
CAGAAGATTTTTTTAAAAGCATGACGGCATATGCCGATCATACGGTGTGGCACGATGTTTACCGACCAGTCTGGAAGAGA
CAAAAACTCTATCTGAAGTTAATCGTCTCTGACGATGTACTGATCGTGTCGTTTAAGGAGAGATAA

Antitoxin


Download         Length: 134 a.a.        Molecular weight: 14933.12 Da        Isoelectric Point: 8.4858

>AT115535 WP_124966951.1 NZ_CP034225:c49716-49315 [Kosakonia sp. CCTCC M2018092]
MKCPVCGAAGLKHDTRNIEYRYKGKVTTLTAIAGDYCDACGEIIFDRLNGEHYSKQVAAFVRKVNAEEVDPQFIATIRKR
FNLDQRQAAEMFGGGANAFSRYETGRVAPPRPLVLLFKALDKHPELFEELKHA

Download         Length: 402 bp

>AT115535 NZ_CP034225:c49716-49315 [Kosakonia sp. CCTCC M2018092]
ATGAAATGCCCTGTTTGCGGCGCTGCGGGACTCAAACATGACACCCGCAACATTGAATACCGTTACAAAGGGAAAGTGAC
TACGCTCACTGCGATTGCAGGCGATTACTGCGACGCATGTGGAGAGATCATTTTCGACCGTCTGAACGGTGAACATTACT
CAAAACAGGTTGCAGCTTTTGTCCGCAAAGTTAACGCCGAAGAAGTTGATCCTCAGTTTATTGCCACCATCCGAAAGCGG
TTTAATCTCGATCAGCGCCAGGCGGCAGAGATGTTTGGCGGCGGCGCAAACGCCTTTAGCCGGTACGAAACCGGGCGTGT
TGCCCCGCCAAGACCTTTAGTTTTGCTCTTTAAGGCGCTGGACAAGCATCCAGAGCTTTTCGAGGAGCTAAAACATGCCT
GA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References