Detailed information of TA system TA115533

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 4410466..4410664
• Replicon: chromosome
• Accession: NZ_CP034213
• Organism: Escherichia albertii strain NCTC 9362

Toxin (Protein)

• Gene name: hokW
• Uniprot ID: -
• Locus tag: DSB70_RS22665
• Protein ID: WP_000813244.1
• Coordinates: 4410509..4410664 (+)
• Length: 52 a.a.

Antitoxin (RNA)

Gene name	sokW
Locus tag	-
Coordinates	4410466..4410497 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DSB70_RS22630	4405813..4406199	+	387	WP_000470023.1	hypothetical protein	-
DSB70_RS22635	4406193..4407713	+	1521	WP_032274375.1	DEAD/DEAH box helicase	-
DSB70_RS22640	4407703..4408674	+	972	WP_032274376.1	primase-helicase zinc-binding domain-containing protein	-
DSB70_RS22645	4408674..4409123	+	450	WP_000402092.1	DUF1367 family protein	-
DSB70_RS22650	4409131..4409694	+	564	WP_032274377.1	recombination protein NinG	-
DSB70_RS22655	4409691..4409891	+	201	WP_000144761.1	phage NinH family protein	-
DSB70_RS22660	4409884..4410309	+	426	WP_001204831.1	antiterminator Q family protein	-
-	4410466..4410497	-	32	-	-	Antitoxin
DSB70_RS22665	4410509..4410664	+	156	WP_000813244.1	Hok/Gef family protein	Toxin
DSB70_RS22670	4410821..4411186	-	366	WP_241201485.1	hypothetical protein	-
DSB70_RS22675	4411267..4413228	+	1962	WP_001178557.1	N-6 DNA methylase	-
DSB70_RS22680	4413297..4414382	+	1086	WP_001340208.1	restriction endonuclease subunit S	-
DSB70_RS22685	4414645..4414797	+	153	WP_001304085.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	4383586..4450764	67178

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-47)

Sequences

Toxin

Protein

• Length: 52 a.a.
• Molecular weight: 5799.99 Da
• Isoelectric Point: 7.7942

>T115533 WP_000813244.1 NZ_CP034213:4410509-4410664 [Escherichia albertii]
MKQQKAMLIALIVICITVVVIALVTRKDFCEVRIRTGQTEVAVFVDYESEK

Nucleotide

• Length: 156 bp

>T115533 NZ_CP034213:4410509-4410664 [Escherichia albertii]
ATGAAGCAGCAAAAGGCGATGTTAATCGCCCTGATCGTCATCTGTATTACCGTCGTAGTGATAGCACTGGTAACGAGGAA
AGACTTCTGCGAGGTACGAATCCGAACCGGCCAGACGGAGGTCGCTGTCTTCGTAGACTACGAATCTGAGAAGTAA

Antitoxin

Nucleotide

• Length: 32 bp

>AT115533 NZ_CP034213:c4410497-4410466 [Escherichia albertii]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTA

Structures

Antitoxin