Detailed information of TA system TA115528

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 3214043..3214300
• Replicon: chromosome
• Accession: NZ_CP034213
• Organism: Escherichia albertii strain NCTC 9362

Toxin (Protein)

• Gene name: hokA
• Uniprot ID: -
• Locus tag: DSB70_RS16325
• Protein ID: WP_032275378.1
• Coordinates: 3214148..3214300 (+)
• Length: 51 a.a.

Antitoxin (RNA)

Gene name	sokA
Locus tag	-
Coordinates	3214043..3214091 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DSB70_RS16300	3209665..3209964	+	300	WP_000979961.1	YsaB family lipoprotein	-
DSB70_RS16305	3210060..3210971	+	912	WP_001168544.1	glycine--tRNA ligase subunit alpha	-
DSB70_RS16310	3210981..3213050	+	2070	WP_125060281.1	glycine--tRNA ligase subunit beta	-
DSB70_RS16315	3213012..3213272	-	261	WP_125060282.1	hypothetical protein	-
DSB70_RS16320	3213171..3213868	+	698	WP_094106546.1	IS1 family transposase	-
-	3214043..3214091	-	49	-	-	Antitoxin
DSB70_RS16325	3214148..3214300	+	153	WP_032275378.1	type I toxin-antitoxin system toxin HokA	Toxin
DSB70_RS16330	3214452..3215138	+	687	WP_125060283.1	hypothetical protein	-
DSB70_RS16335	3215206..3215418	-	213	WP_000014594.1	RNA chaperone/antiterminator CspA	-
DSB70_RS16340	3215701..3215991	-	291	WP_125060284.1	HTH-type transcriptional regulator	-
DSB70_RS16345	3216414..3217124	+	711	WP_002460072.1	DUF3053 domain-containing protein	-
DSB70_RS16350	3217177..3218151	-	975	WP_000804993.1	glyoxylate/hydroxypyruvate reductase GhrB	-
DSB70_RS16355	3218255..3218914	-	660	WP_000747625.1	OmpA family lipoprotein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	3213365..3213868	503

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (5-46)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5762.95 Da
• Isoelectric Point: 8.2833

>T115528 WP_032275378.1 NZ_CP034213:3214148-3214300 [Escherichia albertii]
MPQRYLLFGLVVICFTLLLFTWMVRDSLCELHIKQGSNELATFLACGNKK

Nucleotide

• Length: 153 bp

>T115528 NZ_CP034213:3214148-3214300 [Escherichia albertii]
ATGCCGCAGAGATATTTGTTATTTGGCTTAGTAGTGATTTGTTTCACGCTATTATTATTTACCTGGATGGTAAGAGATTC
ACTGTGTGAATTACATATTAAGCAGGGAAGTAATGAGCTGGCGACATTTTTAGCCTGTGGAAATAAAAAGTAA

Antitoxin

Nucleotide

• Length: 49 bp

>AT115528 NZ_CP034213:c3214091-3214043 [Escherichia albertii]
GCATAGAGGGGCCTCACTTTGATTTATAGTCAGGTGGGGCTTTTCTCTG

Structures

Antitoxin