Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 2297968..2298226 Replicon chromosome
Accession NZ_CP034213
Organism Escherichia albertii strain NCTC 9362

Toxin (Protein)


Gene name hokC Uniprot ID S1NX00
Locus tag DSB70_RS11815 Protein ID WP_000809168.1
Coordinates 2298074..2298226 (+) Length 51 a.a.

Antitoxin (RNA)


Gene name sokA
Locus tag -
Coordinates 2297968..2298025 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DSB70_RS11800 2293776..2295023 - 1248 WP_059227922.1 hypothetical protein -
DSB70_RS11805 2295177..2296670 - 1494 WP_059227924.1 sulfatase-like hydrolase/transferase -
DSB70_RS11810 2296691..2297452 - 762 WP_054409892.1 outer membrane protein OmpK -
- 2297968..2298025 - 58 - - Antitoxin
DSB70_RS11815 2298074..2298226 + 153 WP_000809168.1 type I toxin-antitoxin system toxin MokC Toxin
DSB70_RS11820 2298334..2299464 - 1131 WP_001118445.1 molecular chaperone DnaJ -
DSB70_RS11825 2299553..2301469 - 1917 WP_024249291.1 molecular chaperone DnaK -
DSB70_RS11830 2301843..2302247 + 405 WP_125060010.1 DUF2541 family protein -
DSB70_RS11835 2302274..2302987 + 714 WP_125060011.1 acidic protein MsyB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(6-47)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5501.57 Da        Isoelectric Point: 7.1312

>T115525 WP_000809168.1 NZ_CP034213:2298074-2298226 [Escherichia albertii]
MKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Download         Length: 153 bp

>T115525 NZ_CP034213:2298074-2298226 [Escherichia albertii]
ATGAAGCAGCATAAGGCGATGATTGTCGCCCTGATCGTCATCTGTATCACCGCCGTAGTGGCGGCGCTGGTAACGAGAAA
AGACCTCTGTGAGGTTCACATCCGAACTGGCCAGACGGAGGTTGCTGTTTTCACGGCTTACGAATCCGAGTAA

Antitoxin


Download         Length: 58 bp

>AT115525 NZ_CP034213:c2298025-2297968 [Escherichia albertii]
GTTCTGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1NX00

Antitoxin

Download structure file

References