Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | higBA (relBE)/COG4683-HTH_37 |
Location | 2014433..2015083 | Replicon | chromosome |
Accession | NZ_CP034213 | ||
Organism | Escherichia albertii strain NCTC 9362 |
Toxin (Protein)
Gene name | higB | Uniprot ID | - |
Locus tag | DSB70_RS10470 | Protein ID | WP_059224977.1 |
Coordinates | 2014742..2015083 (-) | Length | 114 a.a. |
Antitoxin (Protein)
Gene name | higA | Uniprot ID | A0A3T5VD61 |
Locus tag | DSB70_RS10465 | Protein ID | WP_025237546.1 |
Coordinates | 2014433..2014732 (-) | Length | 100 a.a. |
Genomic Context
Location: 2013524..2014375 (852 bp)
Type: Others
Protein ID: WP_125059915.1
Type: Others
Protein ID: WP_125059915.1
Location: 2009461..2009772 (312 bp)
Type: Others
Protein ID: WP_000410252.1
Type: Others
Protein ID: WP_000410252.1
Location: 2009777..2010169 (393 bp)
Type: Others
Protein ID: WP_000273381.1
Type: Others
Protein ID: WP_000273381.1
Location: 2010192..2011508 (1317 bp)
Type: Others
Protein ID: WP_000609691.1
Type: Others
Protein ID: WP_000609691.1
Location: 2011575..2011901 (327 bp)
Type: Others
Protein ID: WP_241201543.1
Type: Others
Protein ID: WP_241201543.1
Location: 2012123..2013037 (915 bp)
Type: Others
Protein ID: WP_125059914.1
Type: Others
Protein ID: WP_125059914.1
Location: 2014433..2014732 (300 bp)
Type: Antitoxin
Protein ID: WP_025237546.1
Type: Antitoxin
Protein ID: WP_025237546.1
Location: 2014742..2015083 (342 bp)
Type: Toxin
Protein ID: WP_059224977.1
Type: Toxin
Protein ID: WP_059224977.1
Location: 2015159..2016136 (978 bp)
Type: Others
Protein ID: WP_125059916.1
Type: Others
Protein ID: WP_125059916.1
Location: 2016153..2017082 (930 bp)
Type: Others
Protein ID: WP_125059917.1
Type: Others
Protein ID: WP_125059917.1
Location: 2017097..2018473 (1377 bp)
Type: Others
Protein ID: WP_125059918.1
Type: Others
Protein ID: WP_125059918.1
Location: 2019031..2019330 (300 bp)
Type: Others
Protein ID: WP_059254376.1
Type: Others
Protein ID: WP_059254376.1
Loading, please wait
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
DSB70_RS10435 (2009461) | 2009461..2009772 | - | 312 | WP_000410252.1 | hypothetical protein | - |
DSB70_RS10440 (2009777) | 2009777..2010169 | - | 393 | WP_000273381.1 | flagellar export chaperone FliS | - |
DSB70_RS10445 (2010192) | 2010192..2011508 | - | 1317 | WP_000609691.1 | flagellar filament capping protein FliD | - |
DSB70_RS23745 (2011575) | 2011575..2011901 | - | 327 | WP_241201543.1 | hypothetical protein | - |
DSB70_RS10455 (2012123) | 2012123..2013037 | - | 915 | WP_125059914.1 | lateral flagellin LafA | - |
DSB70_RS10460 (2013524) | 2013524..2014375 | + | 852 | WP_125059915.1 | winged helix-turn-helix domain-containing protein | - |
DSB70_RS10465 (2014433) | 2014433..2014732 | - | 300 | WP_025237546.1 | XRE family transcriptional regulator | Antitoxin |
DSB70_RS10470 (2014742) | 2014742..2015083 | - | 342 | WP_059224977.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
DSB70_RS10475 (2015159) | 2015159..2016136 | - | 978 | WP_125059916.1 | flagellar hook-associated protein | - |
DSB70_RS10480 (2016153) | 2016153..2017082 | - | 930 | WP_125059917.1 | flagellar hook-associated protein FlgL | - |
DSB70_RS10485 (2017097) | 2017097..2018473 | - | 1377 | WP_125059918.1 | flagellar hook-associated protein FlgK | - |
DSB70_RS10490 (2019031) | 2019031..2019330 | - | 300 | WP_059254376.1 | rod-binding protein | - |
Associated MGEs
Loading, please wait
MGE detail | Similar MGEs | Relative position | MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Genomic island | - | - | 1999933..2023215 | 23282 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 114 a.a. Molecular weight: 13017.79 Da Isoelectric Point: 5.7334
>T115524 WP_059224977.1 NZ_CP034213:c2015083-2014742 [Escherichia albertii]
MWDVETTETFDNWFDAQTVALKEDLLAAMLILAEYGPQLGRPFADTVNDSQFSNMKELRVQHQGNPVRAFFAFDPARRGI
VLCAGDKTGLNEKKFYRDMIKLADSEYRNHLKK
MWDVETTETFDNWFDAQTVALKEDLLAAMLILAEYGPQLGRPFADTVNDSQFSNMKELRVQHQGNPVRAFFAFDPARRGI
VLCAGDKTGLNEKKFYRDMIKLADSEYRNHLKK
Download Length: 342 bp
>T115524 NZ_CP034213:c2015083-2014742 [Escherichia albertii]
ATGTGGGACGTCGAGACAACGGAGACTTTCGACAACTGGTTTGATGCCCAGACTGTTGCGCTGAAAGAAGATTTGCTTGC
TGCAATGCTGATTCTTGCAGAGTATGGCCCACAGTTGGGCAGACCCTTTGCGGACACGGTTAATGATTCACAGTTTTCAA
ATATGAAAGAATTACGCGTCCAACATCAGGGAAACCCGGTACGTGCTTTTTTTGCTTTCGATCCTGCGCGCCGTGGCATT
GTATTATGTGCAGGTGATAAAACGGGGTTAAATGAGAAAAAGTTTTATCGCGATATGATCAAGCTCGCTGATTCTGAATA
CCGTAATCATCTGAAAAAGTAA
ATGTGGGACGTCGAGACAACGGAGACTTTCGACAACTGGTTTGATGCCCAGACTGTTGCGCTGAAAGAAGATTTGCTTGC
TGCAATGCTGATTCTTGCAGAGTATGGCCCACAGTTGGGCAGACCCTTTGCGGACACGGTTAATGATTCACAGTTTTCAA
ATATGAAAGAATTACGCGTCCAACATCAGGGAAACCCGGTACGTGCTTTTTTTGCTTTCGATCCTGCGCGCCGTGGCATT
GTATTATGTGCAGGTGATAAAACGGGGTTAAATGAGAAAAAGTTTTATCGCGATATGATCAAGCTCGCTGATTCTGAATA
CCGTAATCATCTGAAAAAGTAA
Antitoxin
Download Length: 100 a.a. Molecular weight: 10962.78 Da Isoelectric Point: 9.7665
>AT115524 WP_025237546.1 NZ_CP034213:c2014732-2014433 [Escherichia albertii]
MATLKELMAKQSPESQARIAAKVEEMRQTIALHQLREELNISQTEMAAAMGIKQPTLAKMEQADNDPRLSTLKRYVAALG
GELSIDVKLPNGKRVAFQI
MATLKELMAKQSPESQARIAAKVEEMRQTIALHQLREELNISQTEMAAAMGIKQPTLAKMEQADNDPRLSTLKRYVAALG
GELSIDVKLPNGKRVAFQI
Download Length: 300 bp
>AT115524 NZ_CP034213:c2014732-2014433 [Escherichia albertii]
ATGGCTACTCTAAAAGAACTGATGGCAAAGCAAAGCCCTGAAAGCCAGGCGCGTATTGCGGCAAAAGTTGAGGAAATGCG
CCAGACCATCGCCTTGCATCAGCTGAGAGAAGAACTCAATATTTCGCAAACGGAAATGGCGGCAGCGATGGGCATTAAGC
AACCGACCCTTGCAAAAATGGAGCAGGCAGATAACGATCCTCGGTTGTCTACGCTAAAACGCTATGTCGCGGCTTTAGGT
GGGGAATTGAGTATCGACGTTAAACTGCCTAATGGTAAGAGAGTTGCATTTCAGATTTAA
ATGGCTACTCTAAAAGAACTGATGGCAAAGCAAAGCCCTGAAAGCCAGGCGCGTATTGCGGCAAAAGTTGAGGAAATGCG
CCAGACCATCGCCTTGCATCAGCTGAGAGAAGAACTCAATATTTCGCAAACGGAAATGGCGGCAGCGATGGGCATTAAGC
AACCGACCCTTGCAAAAATGGAGCAGGCAGATAACGATCCTCGGTTGTCTACGCTAAAACGCTATGTCGCGGCTTTAGGT
GGGGAATTGAGTATCGACGTTAAACTGCCTAATGGTAAGAGAGTTGCATTTCAGATTTAA
Structures
Toxin
Loading, please wait
Source | ID | Structure |
---|---|---|
No matching records found |
Antitoxin
Loading, please wait
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A3T5VD61 |