Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 2014433..2015083 Replicon chromosome
Accession NZ_CP034213
Organism Escherichia albertii strain NCTC 9362

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag DSB70_RS10470 Protein ID WP_059224977.1
Coordinates 2014742..2015083 (-) Length 114 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A3T5VD61
Locus tag DSB70_RS10465 Protein ID WP_025237546.1
Coordinates 2014433..2014732 (-) Length 100 a.a.

Genomic Context


DSB70_RS10460DSB70_RS10435DSB70_RS10440DSB70_RS10445DSB70_RS23745DSB70_RS10455DSB70_RS10465DSB70_RS10470DSB70_RS10475DSB70_RS10480DSB70_RS10485DSB70_RS10490
Location: 2013524..2014375 (852 bp)
Type: Others
Protein ID: WP_125059915.1
Location: 2009461..2009772 (312 bp)
Type: Others
Protein ID: WP_000410252.1
Location: 2009777..2010169 (393 bp)
Type: Others
Protein ID: WP_000273381.1
Location: 2010192..2011508 (1317 bp)
Type: Others
Protein ID: WP_000609691.1
Location: 2011575..2011901 (327 bp)
Type: Others
Protein ID: WP_241201543.1
Location: 2012123..2013037 (915 bp)
Type: Others
Protein ID: WP_125059914.1
Location: 2014433..2014732 (300 bp)
Type: Antitoxin
Protein ID: WP_025237546.1
Location: 2014742..2015083 (342 bp)
Type: Toxin
Protein ID: WP_059224977.1
Location: 2015159..2016136 (978 bp)
Type: Others
Protein ID: WP_125059916.1
Location: 2016153..2017082 (930 bp)
Type: Others
Protein ID: WP_125059917.1
Location: 2017097..2018473 (1377 bp)
Type: Others
Protein ID: WP_125059918.1
Location: 2019031..2019330 (300 bp)
Type: Others
Protein ID: WP_059254376.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
DSB70_RS10435 (2009461)2009461..2009772-312WP_000410252.1hypothetical protein-
DSB70_RS10440 (2009777)2009777..2010169-393WP_000273381.1flagellar export chaperone FliS-
DSB70_RS10445 (2010192)2010192..2011508-1317WP_000609691.1flagellar filament capping protein FliD-
DSB70_RS23745 (2011575)2011575..2011901-327WP_241201543.1hypothetical protein-
DSB70_RS10455 (2012123)2012123..2013037-915WP_125059914.1lateral flagellin LafA-
DSB70_RS10460 (2013524)2013524..2014375+852WP_125059915.1winged helix-turn-helix domain-containing protein-
DSB70_RS10465 (2014433)2014433..2014732-300WP_025237546.1XRE family transcriptional regulatorAntitoxin
DSB70_RS10470 (2014742)2014742..2015083-342WP_059224977.1type II toxin-antitoxin system RelE/ParE family toxinToxin
DSB70_RS10475 (2015159)2015159..2016136-978WP_125059916.1flagellar hook-associated protein-
DSB70_RS10480 (2016153)2016153..2017082-930WP_125059917.1flagellar hook-associated protein FlgL-
DSB70_RS10485 (2017097)2017097..2018473-1377WP_125059918.1flagellar hook-associated protein FlgK-
DSB70_RS10490 (2019031)2019031..2019330-300WP_059254376.1rod-binding protein-

Associated MGEs


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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic island--1999933..202321523282


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(13-107)

Antitoxin

(8-88)


Sequences


Toxin        


Download         Length: 114 a.a.        Molecular weight: 13017.79 Da        Isoelectric Point: 5.7334

>T115524 WP_059224977.1 NZ_CP034213:c2015083-2014742 [Escherichia albertii]
MWDVETTETFDNWFDAQTVALKEDLLAAMLILAEYGPQLGRPFADTVNDSQFSNMKELRVQHQGNPVRAFFAFDPARRGI
VLCAGDKTGLNEKKFYRDMIKLADSEYRNHLKK

Download         Length: 342 bp

>T115524 NZ_CP034213:c2015083-2014742 [Escherichia albertii]
ATGTGGGACGTCGAGACAACGGAGACTTTCGACAACTGGTTTGATGCCCAGACTGTTGCGCTGAAAGAAGATTTGCTTGC
TGCAATGCTGATTCTTGCAGAGTATGGCCCACAGTTGGGCAGACCCTTTGCGGACACGGTTAATGATTCACAGTTTTCAA
ATATGAAAGAATTACGCGTCCAACATCAGGGAAACCCGGTACGTGCTTTTTTTGCTTTCGATCCTGCGCGCCGTGGCATT
GTATTATGTGCAGGTGATAAAACGGGGTTAAATGAGAAAAAGTTTTATCGCGATATGATCAAGCTCGCTGATTCTGAATA
CCGTAATCATCTGAAAAAGTAA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10962.78 Da        Isoelectric Point: 9.7665

>AT115524 WP_025237546.1 NZ_CP034213:c2014732-2014433 [Escherichia albertii]
MATLKELMAKQSPESQARIAAKVEEMRQTIALHQLREELNISQTEMAAAMGIKQPTLAKMEQADNDPRLSTLKRYVAALG
GELSIDVKLPNGKRVAFQI

Download         Length: 300 bp

>AT115524 NZ_CP034213:c2014732-2014433 [Escherichia albertii]
ATGGCTACTCTAAAAGAACTGATGGCAAAGCAAAGCCCTGAAAGCCAGGCGCGTATTGCGGCAAAAGTTGAGGAAATGCG
CCAGACCATCGCCTTGCATCAGCTGAGAGAAGAACTCAATATTTCGCAAACGGAAATGGCGGCAGCGATGGGCATTAAGC
AACCGACCCTTGCAAAAATGGAGCAGGCAGATAACGATCCTCGGTTGTCTACGCTAAAACGCTATGTCGCGGCTTTAGGT
GGGGAATTGAGTATCGACGTTAAACTGCCTAATGGTAAGAGAGTTGCATTTCAGATTTAA

Similar Proteins


Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures


Toxin

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Source
ID
Structure
No matching records found


Antitoxin

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Source
ID
Structure
AlphaFold DBA0A3T5VD61

References