Detailed information of TA system TA115519

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 1075426..1075651
• Replicon: chromosome
• Accession: NZ_CP034213
• Organism: Escherichia albertii strain NCTC 9362

Toxin (Protein)

• Gene name: hokW
• Uniprot ID: S1ELB5
• Locus tag: DSB70_RS05540
• Protein ID: WP_000813254.1
• Coordinates: 1075426..1075581 (-)
• Length: 52 a.a.

Antitoxin (RNA)

Gene name	sokW
Locus tag	-
Coordinates	1075593..1075651 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DSB70_RS05505	1071100..1071474	-	375	WP_032258101.1	helix-turn-helix transcriptional regulator	-
DSB70_RS05510	1071535..1071795	-	261	WP_000573777.1	type II toxin-antitoxin system RelE/ParE family toxin	-
DSB70_RS05515	1071902..1072967	-	1066	Protein_1091	site-specific DNA-methyltransferase	-
DSB70_RS05520	1073118..1073315	-	198	WP_000917767.1	hypothetical protein	-
DSB70_RS05525	1073531..1073911	-	381	WP_001204806.1	antiterminator Q family protein	-
DSB70_RS05530	1073929..1074978	-	1050	WP_125059636.1	DUF968 domain-containing protein	-
DSB70_RS05535	1074980..1075258	-	279	WP_001341388.1	hypothetical protein	-
DSB70_RS05540	1075426..1075581	-	156	WP_000813254.1	type I toxin-antitoxin system toxin HokD	Toxin
-	1075593..1075651	+	59	-	-	Antitoxin
DSB70_RS05545	1075828..1075932	-	105	WP_001278454.1	hypothetical protein	-
DSB70_RS05550	1076048..1076632	-	585	WP_000206794.1	DUF551 domain-containing protein	-
DSB70_RS05555	1076689..1077084	-	396	WP_001118161.1	DUF977 family protein	-
DSB70_RS05560	1077100..1077825	-	726	WP_046122919.1	DUF1627 domain-containing protein	-
DSB70_RS05565	1077847..1078593	-	747	WP_125059637.1	ATP-binding protein	-
DSB70_RS05570	1078600..1079670	-	1071	WP_001262374.1	hypothetical protein	-
DSB70_RS05575	1079742..1080167	-	426	WP_000693883.1	toxin YdaT family protein	-
DSB70_RS05580	1080151..1080432	-	282	WP_000391950.1	YdaS family helix-turn-helix protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	espK / espK	1035555..1096471	60916

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-47)

Sequences

Toxin

Protein

• Length: 52 a.a.
• Molecular weight: 5736.89 Da
• Isoelectric Point: 6.1531

>T115519 WP_000813254.1 NZ_CP034213:c1075581-1075426 [Escherichia albertii]
MKQQKAMLIALIVICLTVIVTALVTRKDLCEVRIRTGQTEVAVFTAYEPEE

Nucleotide

• Length: 156 bp

>T115519 NZ_CP034213:c1075581-1075426 [Escherichia albertii]
ATGAAGCAGCAAAAGGCGATGTTAATCGCCCTGATCGTCATCTGTTTAACCGTCATAGTGACGGCACTGGTAACGAGGAA
AGACCTCTGCGAGGTACGAATCCGAACCGGCCAGACGGAGGTCGCTGTCTTCACAGCTTACGAACCTGAGGAGTAA

Antitoxin

Nucleotide

• Length: 59 bp

>AT115519 NZ_CP034213:1075593-1075651 [Escherichia albertii]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTACATGTGTCTAGCATGAAATTGACCTCA

Structures

Toxin

• AlphaFold DB: A0A4P7TMW0

Antitoxin