Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 742605..743167 Replicon chromosome
Accession NZ_CP034213
Organism Escherichia albertii strain NCTC 9362

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag DSB70_RS03825 Protein ID WP_125059442.1
Coordinates 742605..742883 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID S1PAQ1
Locus tag DSB70_RS03830 Protein ID WP_000781370.1
Coordinates 742883..743167 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DSB70_RS03805 (738585) 738585..739016 - 432 WP_000152289.1 peroxiredoxin OsmC -
DSB70_RS03810 (739283) 739283..739420 + 138 WP_000841563.1 stationary-phase-induced ribosome-associated protein -
DSB70_RS03815 (739577) 739577..741274 + 1698 WP_000433442.1 malate dehydrogenase -
DSB70_RS03820 (741409) 741409..742419 + 1011 WP_059219269.1 alcohol dehydrogenase AdhP -
DSB70_RS03825 (742605) 742605..742883 + 279 WP_125059442.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
DSB70_RS03830 (742883) 742883..743167 + 285 WP_000781370.1 HigA family addiction module antitoxin Antitoxin
DSB70_RS03835 (743395) 743395..744048 - 654 WP_000045636.1 formate dehydrogenase-N subunit gamma -
DSB70_RS03840 (744041) 744041..744925 - 885 WP_001240583.1 formate dehydrogenase N subunit beta -
DSB70_RS03845 (744938) 744938..747985 - 3048 WP_125059444.1 formate dehydrogenase-N subunit alpha -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-88)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10523.16 Da        Isoelectric Point: 7.2751

>T115518 WP_125059442.1 NZ_CP034213:742605-742883 [Escherichia albertii]
MIMNFRHKGLRDLFLLGKTSVVIPTQVKRLRHRLAVIDAASCLADIDMPGYRLPPLSGDRDGIWAISVSGNWRITFEFVN
GDAYILDYEDYH

Download         Length: 279 bp

>T115518 NZ_CP034213:742605-742883 [Escherichia albertii]
ATGATAATGAATTTCAGACACAAGGGATTGCGTGACTTGTTTCTTCTCGGCAAAACCTCCGTCGTTATACCGACGCAAGT
CAAACGATTACGCCACCGACTCGCTGTGATTGATGCAGCAAGCTGTCTTGCTGATATCGATATGCCCGGTTACCGACTAC
CCCCATTAAGCGGCGATCGCGATGGCATCTGGGCAATATCTGTATCAGGCAACTGGCGAATCACGTTTGAGTTCGTCAAT
GGCGATGCATACATACTGGATTACGAGGACTATCACTGA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10401.08 Da        Isoelectric Point: 8.8567

>AT115518 WP_000781370.1 NZ_CP034213:742883-743167 [Escherichia albertii]
MKMANHPRPGDIIQESLDELNVSLREFARAMEIAPSTASRLLTGKAALTPEMAIKLSVVIGSSPQMWLNLQNAWSLAEAE
KTVDVSRLRRLVTQ

Download         Length: 285 bp

>AT115518 NZ_CP034213:742883-743167 [Escherichia albertii]
ATGAAAATGGCCAATCATCCCCGCCCGGGGGACATTATTCAGGAATCACTGGACGAACTGAACGTCAGCCTGCGCGAGTT
TGCCAGAGCAATGGAAATTGCGCCCTCAACGGCAAGCCGACTGTTGACCGGAAAAGCGGCTTTGACGCCAGAAATGGCGA
TTAAACTTTCCGTGGTGATCGGCAGTTCGCCGCAAATGTGGCTGAATCTGCAAAATGCCTGGAGTCTGGCAGAGGCTGAG
AAAACGGTGGATGTGTCGCGGTTGCGCCGTCTGGTGACGCAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 2ICT
PDB 2ICP
AlphaFold DB A0A829CUG6

References