Detailed information of TA system TA115502

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 3606837..3607082
• Replicon: chromosome
• Accession: NZ_CP034212
• Organism: Escherichia albertii strain 2010C-3449

Toxin (Protein)

• Gene name: hokX
• Uniprot ID: L4J2K8
• Locus tag: CCF17_RS18435
• Protein ID: WP_000956460.1
• Coordinates: 3606930..3607082 (+)
• Length: 51 a.a.

Antitoxin (RNA)

Gene name	sokX
Locus tag	-
Coordinates	3606837..3606885 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CCF17_RS18415	3602241..3604040	+	1800	WP_151401942.1	NADPH-dependent assimilatory sulfite reductase flavoprotein subunit	-
CCF17_RS18420	3604040..3605752	+	1713	WP_151401943.1	assimilatory sulfite reductase (NADPH) hemoprotein subunit	-
CCF17_RS18425	3605932..3606666	+	735	WP_025238482.1	phosphoadenosine phosphosulfate reductase	-
-	3606837..3606885	-	49	-	-	Antitoxin
CCF17_RS18435	3606930..3607082	+	153	WP_000956460.1	Hok/Gef family protein	Toxin
CCF17_RS18440	3607208..3608245	-	1038	WP_151401944.1	alkaline phosphatase isozyme conversion aminopeptidase	-
CCF17_RS18445	3608498..3609406	+	909	WP_000372392.1	sulfate adenylyltransferase subunit CysD	-
CCF17_RS18450	3609408..3610835	+	1428	WP_151401945.1	sulfate adenylyltransferase subunit CysN	-
CCF17_RS18455	3610835..3611440	+	606	WP_151402382.1	adenylyl-sulfate kinase	-
CCF17_RS18460	3611490..3611813	+	324	WP_001246114.1	DUF3561 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (5-46)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5602.81 Da
• Isoelectric Point: 7.7899

>T115502 WP_000956460.1 NZ_CP034212:3606930-3607082 [Escherichia albertii]
MLTKYALVAIIVLCFTVLGFTLMVGDSLCELSIRERGMEFKAVLAYESKK

Nucleotide

• Length: 153 bp

>T115502 NZ_CP034212:3606930-3607082 [Escherichia albertii]
ATGCTGACAAAATATGCCCTTGTGGCAATCATAGTGCTGTGTTTCACGGTGCTGGGATTCACGCTGATGGTAGGCGACTC
GCTGTGTGAGTTGAGTATCAGAGAACGTGGTATGGAGTTTAAGGCAGTTCTCGCTTACGAATCGAAGAAGTAG

Antitoxin

Nucleotide

• Length: 49 bp

>AT115502 NZ_CP034212:c3606885-3606837 [Escherichia albertii]
GTTCGAACGTAGGCCTCAGGTTGATAGAAATATCGCCTGGGGCTTTTGT

Structures

Toxin

• AlphaFold DB: A0A829G7J5

Antitoxin