Detailed information of TA system TA115491

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): symER/SymE(toxin)
• Location: 1835998..1836410
• Replicon: chromosome
• Accession: NZ_CP034212
• Organism: Escherichia albertii strain 2010C-3449

Toxin (Protein)

• Gene name: symE
• Uniprot ID: A0A8D9PK47
• Locus tag: CCF17_RS09525
• Protein ID: WP_000132619.1
• Coordinates: 1836069..1836410 (+)
• Length: 114 a.a.

Antitoxin (RNA)

Gene name	symR
Locus tag	-
Coordinates	1835998..1836074 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CCF17_RS09495 (1831962)	1831962..1832165	+	204	WP_000467859.1	YbdD/YjiX family protein	-
CCF17_RS09500 (1832176)	1832176..1833132	+	957	WP_085455854.1	GTPase	-
CCF17_RS09505 (1833218)	1833218..1833409	-	192	WP_149450975.1	antitoxin	-
CCF17_RS09510 (1833450)	1833450..1833755	-	306	WP_241201776.1	hypothetical protein	-
CCF17_RS09520 (1834510)	1834510..1835847	+	1338	Protein_1843	restriction endonuclease subunit S	-
- (1835998)	1835998..1836074	-	77	NuclAT_5	-	Antitoxin
- (1835998)	1835998..1836074	-	77	NuclAT_5	-	Antitoxin
- (1835998)	1835998..1836074	-	77	NuclAT_5	-	Antitoxin
- (1835998)	1835998..1836074	-	77	NuclAT_5	-	Antitoxin
- (1835998)	1835998..1836074	-	77	NuclAT_6	-	Antitoxin
- (1835998)	1835998..1836074	-	77	NuclAT_6	-	Antitoxin
- (1835998)	1835998..1836074	-	77	NuclAT_6	-	Antitoxin
- (1835998)	1835998..1836074	-	77	NuclAT_6	-	Antitoxin
CCF17_RS09525 (1836069)	1836069..1836410	+	342	WP_000132619.1	endoribonuclease SymE	Toxin
CCF17_RS09530 (1836572)	1836572..1837951	+	1380	WP_151401388.1	5-methylcytosine-specific restriction endonuclease subunit McrB	-
CCF17_RS09535 (1837951)	1837951..1838997	+	1047	WP_149450981.1	5-methylcytosine-specific restriction endonuclease system specificity protein McrC	-
CCF17_RS09540 (1839053)	1839053..1840126	-	1074	Protein_1847	DUF1998 domain-containing protein	-
CCF17_RS09545 (1840448)	1840448..1841380	-	933	WP_151401389.1	Rpn family recombination-promoting nuclease/putative transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	1833791..1853150	19359

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SymE-like (20-71)

Sequences

Toxin

Protein

• Length: 114 a.a.
• Molecular weight: 12322.13 Da
• Isoelectric Point: 7.8219

>T115491 WP_000132619.1 NZ_CP034212:1836069-1836410 [Escherichia albertii]
MTDTHSIAQPFEAEVSPANNRQLTVSYASRYPDYSRIPAITLKGQWLEAAGFATGTAVDVKVMEGCIVLTAQPPAPEESE
LMQSLRQVCKLSARKQKQVQEFIGVIAGKQKVA

Nucleotide

• Length: 342 bp

>T115491 NZ_CP034212:1836069-1836410 [Escherichia albertii]
ATGACTGACACGCATTCTATTGCACAACCGTTCGAAGCAGAAGTCTCCCCGGCAAATAACCGTCAATTAACCGTGAGTTA
TGCGAGTCGCTACCCGGATTACAGCCGTATTCCCGCCATCACCCTGAAAGGTCAGTGGCTGGAAGCCGCCGGTTTTGCCA
CCGGCACGGCGGTAGATGTCAAAGTGATGGAAGGCTGTATTGTCCTCACCGCCCAACCACCCGCCCCCGAAGAGAGCGAA
CTGATGCAGTCGCTACGCCAGGTGTGCAAGCTGTCGGCGCGTAAACAGAAGCAGGTGCAGGAGTTTATTGGGGTGATTGC
CGGTAAACAGAAAGTCGCGTAA

Antitoxin

Nucleotide

• Length: 77 bp

>AT115491 NZ_CP034212:c1836074-1835998 [Escherichia albertii]
AGTCATAACTGCTATTCTCCGATAATAGTGATTGTGATGAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Structures

Antitoxin