Detailed information of TA system TA115472

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/Txe-RelB
• Location: 1491701..1492215
• Replicon: chromosome
• Accession: NZ_CP034193
• Organism: Limosilactobacillus fermentum strain YL-11

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: EH277_RS07425
• Protein ID: WP_046949245.1
• Coordinates: 1491701..1491964 (-)
• Length: 88 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: C0WV67
• Locus tag: EH277_RS07430
• Protein ID: WP_003684069.1
• Coordinates: 1491961..1492215 (-)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EH277_RS07410	1487065..1488105	-	1041	WP_046948786.1	Gfo/Idh/MocA family oxidoreductase	-
EH277_RS07415	1488767..1489681	+	915	WP_124891427.1	hypothetical protein	-
EH277_RS07420	1490170..1491291	+	1122	WP_080946703.1	PTS sugar transporter subunit IIC	-
EH277_RS07425	1491701..1491964	-	264	WP_046949245.1	Txe/YoeB family addiction module toxin	Toxin
EH277_RS07430	1491961..1492215	-	255	WP_003684069.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
EH277_RS07435	1492377..1493189	-	813	WP_124891428.1	family 1 glycosylhydrolase	-
EH277_RS07440	1493293..1493952	-	660	WP_046948658.1	3,4-dihydroxy-2-butanone-4-phosphate synthase	-
EH277_RS07445	1494430..1494857	-	428	Protein_1410	hypothetical protein	-
EH277_RS07450	1494838..1495194	-	357	WP_046948659.1	MmcQ/YjbR family DNA-binding protein	-
EH277_RS07455	1495196..1495912	-	717	Protein_1412	sel1 repeat family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (25-86)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (3-55)

Sequences

Toxin

Protein

• Length: 88 a.a.
• Molecular weight: 10284.99 Da
• Isoelectric Point: 10.3799

>T115472 WP_046949245.1 NZ_CP034193:c1491964-1491701 [Limosilactobacillus fermentum]
MSYAIKLKRSANKDLKKIKGSYLEKSFLQIIEQLRKDPLAPNQGFEKLVPPIKGFYSRRINIQHRLVYKVDQDTQTVIIY
SAWSHYE

Nucleotide

• Length: 264 bp

>T115472 NZ_CP034193:c1491964-1491701 [Limosilactobacillus fermentum]
ATGAGTTACGCGATCAAACTCAAGCGGAGCGCTAATAAAGATCTCAAGAAAATTAAGGGGTCATATTTAGAAAAGAGCTT
CTTGCAAATAATTGAGCAGCTCCGTAAAGACCCCTTGGCACCCAACCAAGGCTTTGAAAAATTAGTACCGCCAATTAAGG
GCTTTTACTCCCGGCGGATTAACATTCAGCACCGACTCGTCTATAAGGTTGATCAAGACACGCAAACTGTGATCATCTAT
TCTGCGTGGTCACATTACGAATAG

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9745.04 Da
• Isoelectric Point: 4.4237

>AT115472 WP_003684069.1 NZ_CP034193:c1492215-1491961 [Limosilactobacillus fermentum]
MDQIVTPTQARKDLFKIIKRINENNEPVVIKPTKADEKSVVVIGEDDWKAIQETLFLVNHGVDKQIKERENEPLDDFDDV
WGQL

Nucleotide

• Length: 255 bp

>AT115472 NZ_CP034193:c1492215-1491961 [Limosilactobacillus fermentum]
ATGGACCAAATTGTAACCCCAACGCAAGCACGGAAAGATTTATTCAAAATAATCAAAAGGATCAATGAAAATAATGAGCC
GGTTGTGATTAAGCCGACCAAGGCGGATGAAAAGAGCGTTGTCGTCATTGGTGAAGATGACTGGAAAGCAATCCAAGAAA
CGTTATTTTTGGTTAATCACGGTGTTGACAAGCAAATTAAAGAACGGGAAAACGAGCCGCTCGACGACTTTGATGATGTT
TGGGGTCAACTATGA

Structures

Antitoxin

• AlphaFold DB: A0A806T868