Detailed information of TA system TA115442

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 4565701..4565926
• Replicon: chromosome
• Accession: NZ_CP034166
• Organism: Escherichia albertii strain 2014C-4015

Toxin (Protein)

• Gene name: hokW
• Uniprot ID: A0A7L6L988
• Locus tag: AYR02_RS23535
• Protein ID: WP_000813269.1
• Coordinates: 4565771..4565926 (+)
• Length: 52 a.a.

Antitoxin (RNA)

Gene name	sokW
Locus tag	-
Coordinates	4565701..4565759 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AYR02_RS23495	4560916..4561143	+	228	WP_059278068.1	cell division protein	-
AYR02_RS23500	4561140..4561565	+	426	WP_124783262.1	Rha family transcriptional regulator	-
AYR02_RS23505	4561589..4562551	+	963	WP_072248488.1	helix-turn-helix domain-containing protein	-
AYR02_RS23510	4562558..4563111	+	554	Protein_4294	ATP-binding protein	-
AYR02_RS23515	4563134..4563895	+	762	WP_124783263.1	DUF1627 domain-containing protein	-
AYR02_RS23520	4563903..4564319	+	417	WP_124783264.1	DUF977 family protein	-
AYR02_RS23525	4564478..4564887	+	410	Protein_4297	hypothetical protein	-
AYR02_RS24880	4565034..4565231	+	198	Protein_4298	DUF551 domain-containing protein	-
-	4565701..4565759	-	59	-	-	Antitoxin
AYR02_RS23535	4565771..4565926	+	156	WP_000813269.1	type I toxin-antitoxin system toxin HokD	Toxin
AYR02_RS23540	4566094..4566372	+	279	WP_072256172.1	hypothetical protein	-
AYR02_RS23545	4566374..4567410	+	1037	Protein_4301	DUF968 domain-containing protein	-
AYR02_RS23550	4567411..4567791	+	381	WP_124783265.1	RusA family crossover junction endodeoxyribonuclease	-
AYR02_RS23555	4567788..4568609	+	822	WP_059278988.1	antitermination protein	-
AYR02_RS23570	4569350..4569565	+	216	WP_000839572.1	class II holin family protein	-
AYR02_RS23575	4569569..4570222	+	654	Protein_4305	hypothetical protein	-
AYR02_RS23580	4570267..4570494	+	228	WP_059278985.1	DUF1327 domain-containing protein	-
AYR02_RS23585	4570499..4570786	-	288	WP_059278986.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	4548459..4592291	43832

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-47)

Sequences

Toxin

Protein

• Length: 52 a.a.
• Molecular weight: 5722.86 Da
• Isoelectric Point: 6.1531

>T115442 WP_000813269.1 NZ_CP034166:4565771-4565926 [Escherichia albertii]
MKQQKAMLVALIVICLTVIVTALVTRKDLCEVRIRTGQTEVAVFTAYEPEE

Nucleotide

• Length: 156 bp

>T115442 NZ_CP034166:4565771-4565926 [Escherichia albertii]
ATGAAGCAGCAAAAGGCGATGTTAGTCGCCCTGATCGTCATCTGTTTAACCGTCATTGTTACGGCACTGGTAACGAGGAA
AGACCTCTGCGAGGTACGAATCCGAACCGGTCAGACGGAGGTCGCTGTCTTCACAGCTTACGAACCTGAGGAGTAA

Antitoxin

Nucleotide

• Length: 59 bp

>AT115442 NZ_CP034166:c4565759-4565701 [Escherichia albertii]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTACATGTGTTCAGCATGGATTGAGCCTCA

Structures

Toxin

• AlphaFold DB: A0A7L6L988

Antitoxin