Detailed information of TA system TA115434

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): symE-sokW/SymE(toxin)
• Location: 3161938..3162350
• Replicon: chromosome
• Accession: NZ_CP034166
• Organism: Escherichia albertii strain 2014C-4015

Toxin (Protein)

• Gene name: symE
• Uniprot ID: -
• Locus tag: AYR02_RS16470
• Protein ID: WP_124782872.1
• Coordinates: 3161938..3162279 (-)
• Length: 114 a.a.

Antitoxin (RNA)

Gene name	sokW
Locus tag	-
Coordinates	3162274..3162350 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AYR02_RS16450	3157451..3157900	+	450	WP_164473971.1	Rpn family recombination-promoting nuclease/putative transposase	-
AYR02_RS16455	3158218..3159296	+	1079	Protein_2947	hypothetical protein	-
AYR02_RS16460	3159353..3160399	-	1047	Protein_2948	5-methylcytosine-specific restriction endonuclease system specificity protein McrC	-
AYR02_RS16465	3160399..3161776	-	1378	Protein_2949	5-methylcytosine-specific restriction endonuclease subunit McrB	-
AYR02_RS16470	3161938..3162279	-	342	WP_124782872.1	endoribonuclease SymE	Toxin
-	3162274..3162350	+	77	NuclAT_5	-	Antitoxin
-	3162274..3162350	+	77	NuclAT_5	-	Antitoxin
-	3162274..3162350	+	77	NuclAT_5	-	Antitoxin
-	3162274..3162350	+	77	NuclAT_5	-	Antitoxin
-	3162274..3162350	+	77	NuclAT_6	-	Antitoxin
-	3162274..3162350	+	77	NuclAT_6	-	Antitoxin
-	3162274..3162350	+	77	NuclAT_6	-	Antitoxin
-	3162274..3162350	+	77	NuclAT_6	-	Antitoxin
AYR02_RS16475	3162449..3163906	-	1458	WP_124782873.1	restriction endonuclease subunit S	-
AYR02_RS16480	3163903..3165491	-	1589	Protein_2952	type I restriction-modification system methyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SymE-like (20-71)

Sequences

Toxin

Protein

• Length: 114 a.a.
• Molecular weight: 12341.19 Da
• Isoelectric Point: 8.5043

>T115434 WP_124782872.1 NZ_CP034166:c3162279-3161938 [Escherichia albertii]
MTDTHSIAQPFEPEVSPANNRHVTVSYVSRYPGYSRIPAITLKGQWLEAAGFATGTAVDIKVMEGCIVLTAQPPAPEESE
LMQSLRQVCKLSARKQRQVQDFIGVIAGKQKVA

Nucleotide

• Length: 342 bp

>T115434 NZ_CP034166:c3162279-3161938 [Escherichia albertii]
ATGACTGACACGCATTCTATTGCACAACCGTTCGAACCAGAAGTCTCCCCGGCAAATAACCGTCATGTTACCGTGAGTTA
TGTGAGCCGCTACCCGGGTTACAGCCGTATTCCCGCCATCACCCTGAAAGGTCAGTGGCTGGAAGCCGCCGGTTTTGCTA
CCGGCACGGCGGTAGATATCAAAGTGATGGAAGGCTGTATTGTCCTCACCGCCCAACCACCCGCCCCCGAAGAGAGCGAA
CTGATGCAGTCACTGCGCCAGGTATGCAAATTGTCGGCGCGTAAACAAAGGCAGGTACAGGATTTTATTGGGGTGATTGC
GGGTAAACAGAAAGTCGCGTAA

Antitoxin

Nucleotide

• Length: 77 bp

>AT115434 NZ_CP034166:3162274-3162350 [Escherichia albertii]
AGTCATAACTGCTATTCTCCAGGAATAGTGATTGTGATTAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Structures

Antitoxin