Detailed information of TA system TA115432

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 2311103..2311360
• Replicon: chromosome
• Accession: NZ_CP034166
• Organism: Escherichia albertii strain 2014C-4015

Toxin (Protein)

• Gene name: hokA
• Uniprot ID: V0YDF1
• Locus tag: AYR02_RS12460
• Protein ID: WP_001135738.1
• Coordinates: 2311103..2311255 (-)
• Length: 51 a.a.

Antitoxin (RNA)

Gene name	sokA
Locus tag	-
Coordinates	2311312..2311360 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AYR02_RS12435	2307207..2307866	+	660	WP_000747625.1	OmpA family lipoprotein	-
AYR02_RS12440	2307970..2308944	+	975	WP_059221283.1	glyoxylate/hydroxypyruvate reductase GhrB	-
AYR02_RS12445	2308997..2309707	-	711	WP_002460072.1	DUF3053 domain-containing protein	-
AYR02_RS12450	2310130..2310420	+	291	WP_059221281.1	HTH-type transcriptional regulator	-
AYR02_RS12455	2310703..2310915	+	213	WP_000014594.1	RNA chaperone/antiterminator CspA	-
AYR02_RS12460	2311103..2311255	-	153	WP_001135738.1	type I toxin-antitoxin system toxin HokA	Toxin
-	2311312..2311360	+	49	-	-	Antitoxin
AYR02_RS12465	2311577..2313646	-	2070	WP_124782659.1	glycine--tRNA ligase subunit beta	-
AYR02_RS12470	2313656..2314567	-	912	WP_001168544.1	glycine--tRNA ligase subunit alpha	-
AYR02_RS12475	2314663..2314962	-	300	WP_000979961.1	YsaB family lipoprotein	-
AYR02_RS12480	2315135..2316130	+	996	WP_059221277.1	acyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (5-46)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5912.14 Da
• Isoelectric Point: 7.7173

>T115432 WP_001135738.1 NZ_CP034166:c2311255-2311103 [Escherichia albertii]
MPQKYRLLSLIVICFTLLFFTWMIRDSLCELHIKQGSYELAAFLACNLKE

Nucleotide

• Length: 153 bp

>T115432 NZ_CP034166:c2311255-2311103 [Escherichia albertii]
ATGCCGCAGAAATATAGATTGCTTTCTTTAATAGTGATTTGTTTCACGCTTTTATTTTTCACCTGGATGATAAGGGATTC
ACTGTGTGAATTGCATATTAAACAGGGGAGTTATGAGCTGGCGGCGTTTTTAGCCTGCAATCTGAAAGAGTAA

Antitoxin

Nucleotide

• Length: 49 bp

>AT115432 NZ_CP034166:2311312-2311360 [Escherichia albertii]
GCATAGAGGGGCCTCACTTTAATTTATAGTCAGGTGGGGCTTTTCTCTG

Structures

Toxin

• AlphaFold DB: A0A7U9LX93

Antitoxin