Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 1423159..1423403 Replicon chromosome
Accession NZ_CP034166
Organism Escherichia albertii strain 2014C-4015

Toxin (Protein)


Gene name hokX Uniprot ID S1PD89
Locus tag AYR02_RS08160 Protein ID WP_000956458.1
Coordinates 1423159..1423311 (-) Length 51 a.a.

Antitoxin (RNA)


Gene name sokX
Locus tag -
Coordinates 1423356..1423403 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AYR02_RS08145 1418219..1419781 - 1563 WP_124782403.1 type I-E CRISPR-associated protein Cse1/CasA -
AYR02_RS08150 1419871..1421600 - 1730 Protein_1366 CRISPR-associated helicase Cas3' -
AYR02_RS08155 1421853..1422966 + 1114 Protein_1367 IS4 family transposase -
AYR02_RS08160 1423159..1423311 - 153 WP_000956458.1 type I toxin-antitoxin system Hok family toxin Toxin
- 1423356..1423403 + 48 - - Antitoxin
AYR02_RS08170 1423575..1424309 - 735 WP_001125132.1 phosphoadenosine phosphosulfate reductase -
AYR02_RS08175 1424489..1426201 - 1713 WP_124782404.1 assimilatory sulfite reductase (NADPH) hemoprotein subunit -
AYR02_RS08180 1426201..1428000 - 1800 WP_124782405.1 NADPH-dependent assimilatory sulfite reductase flavoprotein subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(5-46)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5558.77 Da        Isoelectric Point: 7.6757

>T115427 WP_000956458.1 NZ_CP034166:c1423311-1423159 [Escherichia albertii]
MLTKYALVAIIVLCCTVLGFTLMVGDSLCELSIRERGMEFKAVLAYESKK

Download         Length: 153 bp

>T115427 NZ_CP034166:c1423311-1423159 [Escherichia albertii]
ATGCTGACAAAATATGCCCTTGTGGCAATCATCGTACTGTGTTGTACAGTACTGGGATTCACGCTGATGGTAGGCGACTC
GCTGTGTGAGTTGAGTATCAGAGAACGTGGTATGGAGTTTAAGGCAGTTCTCGCTTACGAATCGAAGAAGTAG

Antitoxin


Download         Length: 48 bp

>AT115427 NZ_CP034166:1423356-1423403 [Escherichia albertii]
GTTCGAACGTAGGCCTCAGGTTGATAGAAATATCGCCTGGGGCTTTTG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4P7TJ83

Antitoxin

Download structure file

References