Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 583552..584212 Replicon chromosome
Accession NZ_CP034166
Organism Escherichia albertii strain 2014C-4015

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag AYR02_RS03940 Protein ID WP_124782153.1
Coordinates 583859..584212 (-) Length 118 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag AYR02_RS03935 Protein ID WP_124782152.1
Coordinates 583552..583854 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AYR02_RS03915 579142..579939 + 798 WP_024164886.1 DgsA anti-repressor MtfA -
AYR02_RS03925 580277..581539 + 1263 WP_124782150.1 integrase arm-type DNA-binding domain-containing protein -
AYR02_RS03930 582232..583041 - 810 WP_124782151.1 integrase domain-containing protein -
AYR02_RS24635 583311..583525 + 215 Protein_564 hypothetical protein -
AYR02_RS03935 583552..583854 - 303 WP_124782152.1 XRE family transcriptional regulator Antitoxin
AYR02_RS03940 583859..584212 - 354 WP_124782153.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
AYR02_RS03945 584709..584930 - 222 WP_124782154.1 helix-turn-helix domain-containing protein -
AYR02_RS03950 584927..585394 - 468 WP_124782155.1 hypothetical protein -
AYR02_RS03955 585897..586271 + 375 Protein_569 hypothetical protein -
AYR02_RS03960 586344..587426 + 1083 Protein_570 IS3 family transposase -
AYR02_RS03965 587432..588703 + 1272 Protein_571 AAA family ATPase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - espJ / espFu/tccP / nleC 542045..587484 45439
- flank IS/Tn - - 577660..578856 1196


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-106)

Antitoxin

Cro/C1-type helix-turn-helix domain

(33-81)


Sequences

Toxin        


Download         Length: 118 a.a.        Molecular weight: 13461.35 Da        Isoelectric Point: 9.5699

>T115426 WP_124782153.1 NZ_CP034166:c584212-583859 [Escherichia albertii]
VWTIKTTDTFDRWFTSLNDTDRASVLAALLVLREKGPGLSRPYADTLRGSRYSNMKELRIQSRGDPIRAFFAFDPARTGI
VLCAGNKVGNEKRFYDEMLPVADREFTNWLNILKEKE

Download         Length: 354 bp

>T115426 NZ_CP034166:c584212-583859 [Escherichia albertii]
GTGTGGACGATTAAAACAACGGATACGTTTGATCGCTGGTTTACCTCGCTCAACGATACCGACAGGGCCAGCGTGCTTGC
AGCGCTGTTGGTCCTGCGGGAAAAGGGGCCGGGTTTGTCCAGACCCTATGCCGATACGCTCAGAGGCTCCCGCTACAGCA
ACATGAAAGAACTGCGTATTCAGAGCCGGGGCGATCCGATACGAGCGTTTTTCGCTTTTGACCCGGCCCGTACCGGCATT
GTGCTTTGTGCCGGAAATAAAGTTGGCAATGAAAAACGTTTTTACGATGAGATGCTCCCGGTCGCAGACCGGGAATTCAC
GAACTGGCTGAACATATTAAAAGAGAAGGAGTAA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11012.80 Da        Isoelectric Point: 5.7316

>AT115426 WP_124782152.1 NZ_CP034166:c583854-583552 [Escherichia albertii]
MGRTLEQLIADEKPEVVAEAQAMATDILLNIHLAELREKVQKTQVEMAQALGIKQPTVAGMEKPGRDLKLSTLKRYVEAT
GGKLRLDVELPDGSHYGFVL

Download         Length: 303 bp

>AT115426 NZ_CP034166:c583854-583552 [Escherichia albertii]
ATGGGCAGAACGCTGGAACAGCTTATTGCGGATGAAAAACCTGAAGTCGTGGCCGAAGCTCAGGCGATGGCGACGGACAT
CCTGCTCAACATTCATCTTGCTGAGTTGCGTGAGAAAGTACAGAAAACGCAGGTCGAAATGGCGCAGGCGCTGGGCATCA
AGCAACCTACTGTTGCAGGAATGGAAAAACCAGGGCGCGACCTGAAGCTTTCCACGCTTAAACGCTACGTTGAAGCGACC
GGCGGCAAGCTACGCCTTGATGTTGAACTGCCGGATGGTTCTCACTACGGATTTGTACTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References