Detailed information of TA system TA115424

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 576055..576280
• Replicon: chromosome
• Accession: NZ_CP034166
• Organism: Escherichia albertii strain 2014C-4015

Toxin (Protein)

• Gene name: hokW
• Uniprot ID: A0A8H9SPE4
• Locus tag: AYR02_RS03880
• Protein ID: WP_001406737.1
• Coordinates: 576055..576210 (-)
• Length: 52 a.a.

Antitoxin (RNA)

Gene name	sokW
Locus tag	-
Coordinates	576222..576280 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AYR02_RS03825	571298..571513	-	216	WP_000839596.1	phage lysis protein EssD	-
AYR02_RS03830	572228..572791	+	564	WP_024246368.1	DUF1440 domain-containing protein	-
AYR02_RS03860	573475..574164	-	690	WP_059269179.1	antiterminator	-
AYR02_RS03865	574161..574526	-	366	WP_059278097.1	RusA family crossover junction endodeoxyribonuclease	-
AYR02_RS03870	574527..575579	-	1053	Protein_555	DUF968 domain-containing protein	-
AYR02_RS03875	575581..575859	-	279	WP_032154696.1	hypothetical protein	-
AYR02_RS03880	576055..576210	-	156	WP_001406737.1	type I toxin-antitoxin system toxin HokD	Toxin
-	576222..576280	+	59	-	-	Antitoxin
AYR02_RS24810	576761..576958	-	198	Protein_558	DUF551 domain-containing protein	-
AYR02_RS03895	577105..577428	-	324	Protein_559	hypothetical protein	-
AYR02_RS03900	577660..578856	+	1197	WP_124781948.1	IS110 family transposase	-
AYR02_RS03915	579142..579939	+	798	WP_024164886.1	DgsA anti-repressor MtfA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	espJ / espFu/tccP / nleC	542045..587484	45439
	-	flank	IS/Tn	-	-	577660..578856	1196

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-47)

Sequences

Toxin

Protein

• Length: 52 a.a.
• Molecular weight: 5794.93 Da
• Isoelectric Point: 4.8535

>T115424 WP_001406737.1 NZ_CP034166:c576210-576055 [Escherichia albertii]
MKQQKAMLIALIVICLTVIVTALVTRKDLCEVRIRTDQTEVAVFTAYEPEE

Nucleotide

• Length: 156 bp

>T115424 NZ_CP034166:c576210-576055 [Escherichia albertii]
ATGAAGCAGCAAAAGGCGATGTTAATCGCCCTGATCGTCATCTGTTTAACCGTCATAGTGACGGCACTGGTAACGAGGAA
AGACCTCTGCGAGGTACGAATCCGAACCGACCAGACGGAGGTCGCTGTCTTCACAGCTTACGAACCTGAGGAGTAA

Antitoxin

Nucleotide

• Length: 59 bp

>AT115424 NZ_CP034166:576222-576280 [Escherichia albertii]
CCTTGCCTTTCGGCACGTAAGAGGCTAATCTACATGTGTCTAGCATGAAATTGGCCTCA

Structures

Antitoxin