Detailed information of TA system TA115399

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hokW-symR/-
• Location: 1467329..1467554
• Replicon: chromosome
• Accession: NZ_CP034162
• Organism: Escherichia albertii strain 06-3542

Toxin (Protein)

• Gene name: hokW
• Uniprot ID: A0A7L6L988
• Locus tag: CCS91_RS07395
• Protein ID: WP_000813269.1
• Coordinates: 1467329..1467484 (-)
• Length: 52 a.a.

Antitoxin (RNA)

Gene name	symR
Locus tag	-
Coordinates	1467496..1467554 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CCS91_RS07345	1462450..1462737	+	288	WP_059278986.1	hypothetical protein	-
CCS91_RS07350	1462742..1462969	-	228	WP_059278985.1	DUF1327 domain-containing protein	-
CCS91_RS07355	1463014..1463667	-	654	Protein_1404	hypothetical protein	-
CCS91_RS07360	1463671..1463886	-	216	WP_000839572.1	class II holin family protein	-
CCS91_RS07375	1464627..1465448	-	822	WP_059278988.1	antitermination protein	-
CCS91_RS07380	1465445..1465825	-	381	WP_124783265.1	RusA family crossover junction endodeoxyribonuclease	-
CCS91_RS07385	1465826..1466881	-	1056	WP_124866180.1	DUF968 domain-containing protein	-
CCS91_RS07390	1466883..1467161	-	279	WP_072256172.1	hypothetical protein	-
CCS91_RS07395	1467329..1467484	-	156	WP_000813269.1	type I toxin-antitoxin system toxin HokD	Toxin
-	1467496..1467554	+	59	-	-	Antitoxin
CCS91_RS24135	1468024..1468218	-	195	Protein_1411	DUF551 domain-containing protein	-
CCS91_RS07405	1468368..1468776	-	409	Protein_1412	hypothetical protein	-
CCS91_RS07410	1468935..1469351	-	417	WP_124866055.1	DUF977 family protein	-
CCS91_RS07415	1469359..1470120	-	762	WP_124866054.1	DUF1627 domain-containing protein	-
CCS91_RS07420	1470143..1470889	-	747	WP_113649818.1	ATP-binding protein	-
CCS91_RS07425	1470896..1471858	-	963	WP_072248488.1	helix-turn-helix domain-containing protein	-
CCS91_RS07430	1471882..1472307	-	426	WP_113649817.1	Rha family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1437931..1478906	40975

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-47)

Sequences

Toxin

Protein

• Length: 52 a.a.
• Molecular weight: 5722.86 Da
• Isoelectric Point: 6.1531

>T115399 WP_000813269.1 NZ_CP034162:c1467484-1467329 [Escherichia albertii]
MKQQKAMLVALIVICLTVIVTALVTRKDLCEVRIRTGQTEVAVFTAYEPEE

Nucleotide

• Length: 156 bp

>T115399 NZ_CP034162:c1467484-1467329 [Escherichia albertii]
ATGAAGCAGCAAAAGGCGATGTTAGTCGCCCTGATCGTCATCTGTTTAACCGTCATTGTTACGGCACTGGTAACGAGGAA
AGACCTCTGCGAGGTACGAATCCGAACCGGTCAGACGGAGGTCGCTGTCTTCACAGCTTACGAACCTGAGGAGTAA

Antitoxin

Nucleotide

• Length: 59 bp

>AT115399 NZ_CP034162:1467496-1467554 [Escherichia albertii]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTACATGTGTTCAGCATGGATTGAGCCTCA

Structures

Toxin

• AlphaFold DB: A0A7L6L988

Antitoxin