Detailed information of TA system TA115371

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): DinJ-YafQ (relBE)/YafQ(toxin)
• Location: 1299688..1300276
• Replicon: chromosome
• Accession: NZ_CP034147
• Organism: Helicobacter pylori strain HP14039

Toxin (Protein)

• Gene name: TfiT
• Uniprot ID: -
• Locus tag: EAL91_RS06400
• Protein ID: WP_033756305.1
• Coordinates: 1299688..1299969 (-)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: TfiA
• Uniprot ID: -
• Locus tag: EAL91_RS06405
• Protein ID: WP_033756304.1
• Coordinates: 1299962..1300276 (-)
• Length: 105 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EAL91_RS06365	1294907..1295170	+	264	WP_033756313.1	hypothetical protein	-
EAL91_RS06370	1295167..1295466	+	300	WP_000660142.1	hypothetical protein	-
EAL91_RS06375	1295466..1296407	+	942	WP_033756312.1	Flp pilus assembly complex ATPase component TadA	-
EAL91_RS06380	1296404..1296859	+	456	WP_033756311.1	hypothetical protein	-
EAL91_RS06385	1296856..1297146	+	291	WP_033756309.1	hypothetical protein	-
EAL91_RS06390	1297147..1297704	+	558	WP_033756307.1	hypothetical protein	-
EAL91_RS06395	1297705..1299450	+	1746	WP_033756306.1	type IV secretory system conjugative DNA transfer family protein	-
EAL91_RS06400	1299688..1299969	-	282	WP_033756305.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	Toxin
EAL91_RS06405	1299962..1300276	-	315	WP_033756304.1	hypothetical protein	Antitoxin
EAL91_RS06410	1300566..1302479	+	1914	WP_033756303.1	relaxase/mobilization nuclease domain-containing protein	-
EAL91_RS06415	1302504..1303682	-	1179	WP_033756301.1	hypothetical protein	-
EAL91_RS06420	1303726..1304010	-	285	WP_000394655.1	hypothetical protein	-
EAL91_RS06425	1304092..1304748	-	657	WP_108363218.1	ParA family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	sabA/hopP / flgR / fliP / wbpB / futB / hopH	1177511..1363289	185778

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-91)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10875.80 Da
• Isoelectric Point: 9.5726

>T115371 WP_033756305.1 NZ_CP034147:c1299969-1299688 [Helicobacter pylori]
MLKVRTKKDFLKDFNKHILSGRITESDVTGIVDCLKEQKPLQQKYCDHALSGNLKGLRECHVKPNLLLIYEIKKQENELV
LLRLDTHSELFKK

Nucleotide

• Length: 282 bp

>T115371 NZ_CP034147:c1299969-1299688 [Helicobacter pylori]
ATGCTTAAAGTCAGAACTAAGAAAGATTTTCTTAAAGACTTTAATAAGCATATCTTATCTGGGCGTATTACAGAGAGTGA
TGTTACAGGCATTGTTGATTGCCTAAAAGAACAAAAACCACTCCAACAAAAATATTGCGACCATGCCTTGAGTGGCAATC
TTAAAGGGTTGAGAGAATGCCATGTCAAGCCAAACTTATTATTGATTTATGAAATCAAAAAACAAGAAAACGAACTTGTT
TTATTGCGTCTAGACACTCATAGCGAGCTATTTAAAAAGTGA

Antitoxin

Protein

• Length: 105 a.a.
• Molecular weight: 12180.63 Da
• Isoelectric Point: 5.6761

>AT115371 WP_033756304.1 NZ_CP034147:c1300276-1299962 [Helicobacter pylori]
MSNVITDYSQYNEKQLHNFLNSIEKQLLKAEGDKNKAIKKIQECELQERMIRQVLAQKHSQEKEPTPSLLNTIASKDDPE
YDVSFGDFNDFLQIAKQERERHNA

Nucleotide

• Length: 315 bp

>AT115371 NZ_CP034147:c1300276-1299962 [Helicobacter pylori]
ATGTCAAATGTTATTACAGATTACTCGCAATACAATGAAAAGCAACTGCACAATTTCTTAAACTCCATTGAAAAACAATT
GCTTAAGGCAGAAGGGGATAAAAATAAAGCGATAAAAAAAATCCAAGAGTGTGAATTGCAAGAACGAATGATCAGACAAG
TTTTAGCCCAAAAACATTCTCAAGAAAAAGAACCCACACCAAGTTTGTTAAATACGATCGCTTCAAAAGATGACCCAGAA
TACGATGTTTCGTTTGGAGACTTCAATGATTTTTTGCAAATAGCAAAACAAGAAAGAGAAAGGCATAATGCTTAA