Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 3474509..3475114 Replicon chromosome
Accession NZ_CP034142
Organism Marinobacter sp. NP-4(2019)

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag EHN06_RS15865 Protein ID WP_127333499.1
Coordinates 3474836..3475114 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag EHN06_RS15860 Protein ID WP_011786638.1
Coordinates 3474509..3474823 (-) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EHN06_RS15830 3469974..3471029 + 1056 WP_127333493.1 succinylglutamate desuccinylase -
EHN06_RS15835 3471047..3471541 - 495 WP_127333494.1 gamma-glutamylcyclotransferase -
EHN06_RS15840 3471630..3472550 - 921 WP_127333495.1 M14 family metallocarboxypeptidase -
EHN06_RS15845 3472547..3472843 - 297 WP_127333496.1 hypothetical protein -
EHN06_RS15850 3473141..3473641 - 501 WP_206075799.1 HPP family protein -
EHN06_RS15855 3473757..3474326 + 570 WP_127333498.1 TetR/AcrR family transcriptional regulator -
EHN06_RS15860 3474509..3474823 - 315 WP_011786638.1 HigA family addiction module antidote protein Antitoxin
EHN06_RS15865 3474836..3475114 - 279 WP_127333499.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
EHN06_RS15870 3475278..3475970 - 693 WP_127333500.1 transposase -
EHN06_RS15880 3477289..3478356 - 1068 WP_127333501.1 DUF91 domain-containing protein -
EHN06_RS15885 3478359..3478679 - 321 WP_127333502.1 hypothetical protein -
EHN06_RS15890 3478751..3479536 - 786 WP_127333503.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 3455128..3494886 39758


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(3-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(23-70)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10783.24 Da        Isoelectric Point: 8.5359

>T115368 WP_127333499.1 NZ_CP034142:c3475114-3474836 [Marinobacter sp. NP-4(2019)]
MIKSFKCKHTEELVKTGKTRRFNAIQRTAERKLQQMLSAEALKDLKSPPGNRLEPLSGDREGQHSIRINDQWRLCFRWTD
EGAEDVEIVDYH

Download         Length: 279 bp

>T115368 NZ_CP034142:c3475114-3474836 [Marinobacter sp. NP-4(2019)]
ATGATCAAGAGCTTTAAGTGCAAGCACACAGAGGAGCTTGTAAAAACAGGTAAGACTCGGCGTTTCAATGCAATCCAGCG
AACGGCCGAGCGTAAGTTACAGCAGATGCTAAGCGCTGAAGCTCTTAAAGATTTAAAGTCTCCGCCCGGGAATAGACTTG
AGCCGCTTTCTGGAGACAGAGAGGGGCAACACAGCATCCGGATCAATGACCAGTGGCGATTGTGTTTCCGCTGGACAGAT
GAAGGGGCGGAAGACGTGGAGATTGTTGATTACCACTAA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 12056.91 Da        Isoelectric Point: 9.4576

>AT115368 WP_011786638.1 NZ_CP034142:c3474823-3474509 [Marinobacter sp. NP-4(2019)]
MVTVGMRPIHPGEILLEDYLEPLGMSVNALSKELYVPAQRLNEIVRERRGVTADTAMRLARYFGTTEQFWLNLQTDYDLR
RVRAEKSDQIKKLIKPRKSDHEAA

Download         Length: 315 bp

>AT115368 NZ_CP034142:c3474823-3474509 [Marinobacter sp. NP-4(2019)]
ATGGTTACTGTAGGTATGCGCCCTATCCATCCAGGAGAGATTTTACTTGAGGATTACCTTGAGCCTCTTGGCATGAGTGT
GAATGCGCTTTCAAAAGAACTTTATGTTCCTGCACAGCGCCTGAACGAGATTGTTCGCGAGCGTCGTGGTGTGACCGCGG
ATACGGCCATGCGTTTGGCTCGTTACTTTGGGACTACTGAGCAGTTTTGGCTCAATCTGCAGACCGATTATGATCTGCGT
CGTGTCCGTGCGGAGAAATCCGATCAAATCAAGAAGCTCATCAAGCCTCGAAAGTCTGATCACGAGGCTGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References