Detailed information of TA system TA115367

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HigB-HigA
• Location: 3454706..3455439
• Replicon: chromosome
• Accession: NZ_CP034142
• Organism: Marinobacter sp. NP-4(2019)

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: EHN06_RS15725
• Protein ID: WP_127333476.1
• Coordinates: 3455128..3455439 (-)
• Length: 104 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: EHN06_RS15720
• Protein ID: WP_127333475.1
• Coordinates: 3454706..3455122 (-)
• Length: 139 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EHN06_RS15685	3449943..3450383	-	441	WP_127333468.1	thioredoxin TrxC	-
EHN06_RS15690	3450516..3451274	-	759	WP_127333469.1	TIGR01458 family HAD-type hydrolase	-
EHN06_RS15695	3451382..3451672	+	291	WP_127333470.1	DUF3175 domain-containing protein	-
EHN06_RS15700	3451760..3452617	-	858	WP_127333471.1	ion transporter	-
EHN06_RS15705	3452666..3453121	-	456	WP_127333472.1	CopD family protein	-
EHN06_RS15710	3453254..3454036	-	783	WP_127333473.1	helix-turn-helix transcriptional regulator	-
EHN06_RS15715	3454188..3454595	+	408	WP_127333474.1	hypothetical protein	-
EHN06_RS15720	3454706..3455122	-	417	WP_127333475.1	transcriptional regulator	Antitoxin
EHN06_RS15725	3455128..3455439	-	312	WP_127333476.1	type II toxin-antitoxin system HigB family toxin	Toxin
EHN06_RS15730	3455561..3456016	-	456	WP_127333477.1	hypothetical protein	-
EHN06_RS15740	3457041..3457337	-	297	WP_127333478.1	type VI secretion system PAAR protein	-
EHN06_RS15745	3457438..3459219	-	1782	WP_127333479.1	DEAD/DEAH box helicase	-
EHN06_RS15750	3459567..3459773	+	207	WP_012136625.1	cold-shock protein	-
EHN06_RS15755	3459949..3460428	-	480	WP_127333480.1	peptidylprolyl isomerase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, mRNA interferase HigB (20-93)

Antitoxin

• Antitoxin HigA (5-138)

Sequences

Toxin

Protein

• Length: 104 a.a.
• Molecular weight: 12586.23 Da
• Isoelectric Point: 9.7734

>T115367 WP_127333476.1 NZ_CP034142:c3455439-3455128 [Marinobacter sp. NP-4(2019)]
VHVISRRPFNDAARKFPNDREALVNTYITLRNGQFDTPEELRHVFPSLDNFKYRDKWWVIDIGGNNIRLIAFIEFRDNRM
YVKHICSHAEYDRLTEKYRRNRE

Nucleotide

• Length: 312 bp

>T115367 NZ_CP034142:c3455439-3455128 [Marinobacter sp. NP-4(2019)]
GTGCACGTAATTTCAAGGAGACCGTTCAACGATGCAGCCAGAAAGTTTCCCAACGACAGAGAGGCGTTGGTCAATACTTA
CATAACGCTGCGGAATGGCCAGTTCGATACGCCGGAAGAGCTACGCCACGTGTTCCCATCCCTGGACAATTTCAAGTACA
GAGACAAATGGTGGGTTATCGATATTGGTGGGAACAACATACGGCTGATTGCCTTCATCGAATTCCGTGACAATCGTATG
TACGTGAAACATATATGCAGCCATGCCGAGTACGATCGGCTGACTGAGAAATACCGTCGCAATCGGGAGTAA

Antitoxin

Protein

• Length: 139 a.a.
• Molecular weight: 15158.36 Da
• Isoelectric Point: 4.6545

>AT115367 WP_127333475.1 NZ_CP034142:c3455122-3454706 [Marinobacter sp. NP-4(2019)]
MVSPAVVQIRDALAQLPFLAHIETPDDYERALELMDQLVDDYDSNKPLIEILAVSIERWEDHAEEFSDFNAAVAGTDRGI
AVLKTLMAQHGLGVADLPELGSKGNVSKILNGADGKKLTRKHIEALCKRFGVSPVLFF

Nucleotide

• Length: 417 bp

>AT115367 NZ_CP034142:c3455122-3454706 [Marinobacter sp. NP-4(2019)]
ATGGTATCGCCTGCTGTTGTCCAAATCAGAGATGCGTTGGCCCAATTGCCTTTCCTGGCTCATATAGAGACGCCAGATGA
CTATGAGCGAGCGCTGGAGTTAATGGATCAGTTGGTGGACGACTATGACTCCAATAAACCGCTAATTGAGATTCTGGCCG
TCAGCATTGAGCGCTGGGAGGACCACGCTGAAGAGTTCTCCGATTTTAATGCGGCGGTTGCTGGAACAGATCGGGGTATT
GCTGTGCTTAAAACCCTGATGGCTCAACATGGACTTGGGGTTGCTGATCTGCCAGAGCTGGGTTCAAAGGGCAACGTTAG
CAAAATTCTCAACGGCGCTGATGGTAAAAAGCTGACACGCAAACATATTGAAGCCCTTTGTAAGCGGTTTGGCGTTTCTC
CGGTGCTGTTTTTTTGA