Detailed information of TA system TA115285

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/COG4683-HTH_37
• Location: 1777670..1778339
• Replicon: chromosome
• Accession: NZ_CP034110
• Organism: Avibacterium paragallinarum strain FARPER-174

Toxin (Protein)

• Gene name: higB
• Uniprot ID: A0A380X0Q1
• Locus tag: EIA51_RS08425
• Protein ID: WP_017807010.1
• Coordinates: 1777974..1778339 (-)
• Length: 122 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: EIA51_RS08420
• Protein ID: WP_017807009.1
• Coordinates: 1777670..1777972 (-)
• Length: 101 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EIA51_RS08405	1774297..1775172	-	876	WP_017807006.1	VirK/YbjX family protein	-
EIA51_RS08410	1775288..1776628	-	1341	WP_017807007.1	argininosuccinate synthase	-
EIA51_RS08415	1776719..1777558	-	840	WP_017807008.1	SDR family oxidoreductase	-
EIA51_RS08420	1777670..1777972	-	303	WP_017807009.1	XRE family transcriptional regulator	Antitoxin
EIA51_RS08425	1777974..1778339	-	366	WP_017807010.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
EIA51_RS08430	1778589..1779449	-	861	WP_035686936.1	phosphoribosylaminoimidazolesuccinocarboxamide synthase	-
EIA51_RS08435	1779631..1781220	+	1590	WP_035686939.1	peptide chain release factor 3	-
EIA51_RS08440	1781545..1782390	-	846	WP_017807013.1	elongation factor Ts	-
EIA51_RS08445	1782522..1783250	-	729	WP_017807014.1	30S ribosomal protein S2	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (16-110)

Antitoxin

• Cro/C1-type helix-turn-helix domain (32-81)

Sequences

Toxin

Protein

• Length: 122 a.a.
• Molecular weight: 14098.33 Da
• Isoelectric Point: 4.9436

>T115285 WP_017807010.1 NZ_CP034110:c1778339-1777974 [Avibacterium paragallinarum]
MKQEWEVILQDPLLNWLETLAEDDLLKVYAALALLSTEGPQLGRPYADTIQGSKYTNLKELRVQSKLSVFRLFYIFDPIR
QAIVLCGGDKKGKKEKLFYKEMITLAEQTYDNYLSEFLKEQ

Nucleotide

• Length: 366 bp

>T115285 NZ_CP034110:c1778339-1777974 [Avibacterium paragallinarum]
ATGAAACAAGAATGGGAAGTTATTTTACAAGACCCACTTTTAAATTGGCTTGAAACATTAGCAGAAGATGACTTATTAAA
AGTCTATGCGGCATTAGCGTTATTATCAACAGAAGGACCGCAATTAGGCAGACCTTATGCCGATACTATTCAAGGTTCTA
AATATACCAATTTAAAAGAATTGAGAGTACAGTCTAAATTATCCGTTTTCCGTTTGTTTTATATATTTGATCCCATTCGA
CAGGCTATTGTGCTATGTGGGGGAGATAAAAAAGGCAAAAAAGAAAAGCTCTTTTACAAAGAGATGATCACACTTGCCGA
ACAAACTTATGATAATTACCTTTCTGAATTTTTAAAGGAGCAATAA

Antitoxin

Protein

• Length: 101 a.a.
• Molecular weight: 11238.21 Da
• Isoelectric Point: 9.5655

>AT115285 WP_017807009.1 NZ_CP034110:c1777972-1777670 [Avibacterium paragallinarum]
MSVAFKDLMNKLPAEKQAKVKAIADDMRMELQLYRIREELELSQKQMAEALNISQPSVVALEKRGNDIKLSSVKRYIEAM
GGVLNLSIELPTGKTVTFNL

Nucleotide

• Length: 303 bp

>AT115285 NZ_CP034110:c1777972-1777670 [Avibacterium paragallinarum]
ATGAGCGTAGCATTTAAAGATTTAATGAATAAACTGCCAGCAGAAAAGCAAGCCAAAGTAAAAGCGATAGCAGATGATAT
GCGAATGGAATTACAACTTTATCGCATTCGTGAAGAATTGGAGCTTTCCCAAAAGCAAATGGCGGAAGCTTTGAATATTT
CTCAGCCATCAGTTGTTGCACTTGAGAAACGGGGTAATGATATAAAATTATCATCAGTGAAGCGTTATATTGAAGCAATG
GGCGGTGTTCTAAATTTATCTATTGAATTGCCTACTGGGAAAACCGTAACATTTAACTTATAA

Structures

Toxin

• AlphaFold DB: A0A380X0Q1