Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 1225517..1226186 Replicon chromosome
Accession NZ_CP034110
Organism Avibacterium paragallinarum strain FARPER-174

Toxin (Protein)


Gene name higB Uniprot ID A0A0F5ET33
Locus tag EIA51_RS05985 Protein ID WP_017806586.1
Coordinates 1225827..1226186 (-) Length 120 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A0F5EZ21
Locus tag EIA51_RS05980 Protein ID WP_017806585.1
Coordinates 1225517..1225825 (-) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EIA51_RS05965 1221430..1221909 + 480 WP_017806582.1 leucine-responsive transcriptional regulator Lrp -
EIA51_RS05970 1221911..1224763 + 2853 WP_035684736.1 DNA translocase FtsK -
EIA51_RS05975 1224845..1225465 + 621 WP_035684733.1 outer membrane lipoprotein chaperone LolA -
EIA51_RS05980 1225517..1225825 - 309 WP_017806585.1 helix-turn-helix transcriptional regulator Antitoxin
EIA51_RS05985 1225827..1226186 - 360 WP_017806586.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
EIA51_RS05990 1226374..1227722 + 1349 Protein_1161 replication-associated recombination protein A -
EIA51_RS05995 1227796..1229085 + 1290 WP_035684727.1 serine--tRNA ligase -
EIA51_RS06000 1229289..1230371 + 1083 WP_035684725.1 peptide chain release factor 1 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(18-110)

Antitoxin

Cro/C1-type helix-turn-helix domain

(35-87)


Sequences

Toxin        


Download         Length: 120 a.a.        Molecular weight: 13935.24 Da        Isoelectric Point: 10.3916

>T115283 WP_017806586.1 NZ_CP034110:c1226186-1225827 [Avibacterium paragallinarum]
MVVKKKWEVIATARFKIWLKEQDEATRISVFNALNNLRFYGPQLSRPYVDTIKGSQYPNMKELRIQHKSKPLRAFFAFDP
LRQAIVLCAGNKSNNKQFYKQMITIADAEFTDYLATLEK

Download         Length: 360 bp

>T115283 NZ_CP034110:c1226186-1225827 [Avibacterium paragallinarum]
ATGGTGGTAAAGAAAAAATGGGAAGTCATTGCAACAGCGAGATTTAAAATATGGTTAAAAGAGCAAGATGAGGCTACAAG
GATTTCTGTTTTTAATGCATTAAATAATTTGCGGTTCTATGGTCCTCAATTATCTCGTCCCTATGTAGATACCATAAAAG
GTTCTCAATATCCCAATATGAAAGAGTTGCGTATTCAACATAAAAGCAAGCCACTACGAGCATTTTTTGCATTCGATCCG
CTCAGGCAAGCAATTGTTCTATGTGCTGGAAATAAAAGTAATAATAAACAATTTTACAAACAAATGATTACGATTGCAGA
TGCAGAATTTACCGATTATTTAGCCACATTGGAGAAATAA

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11378.12 Da        Isoelectric Point: 4.3491

>AT115283 WP_017806585.1 NZ_CP034110:c1225825-1225517 [Avibacterium paragallinarum]
MTQYTTLDELIAQESPETQQCIKEMSEELILETGLAMIREQLALSQKELAQAIGVSQSAIAQIEQRGNDVKLSTLKRYIE
KMGGELSLTVKMPTGYSQIFPL

Download         Length: 309 bp

>AT115283 NZ_CP034110:c1225825-1225517 [Avibacterium paragallinarum]
ATGACACAATATACTACACTTGATGAGCTTATCGCTCAAGAATCCCCTGAAACACAACAATGCATTAAAGAAATGTCCGA
AGAACTCATTCTAGAAACCGGTCTTGCAATGATCCGCGAACAACTCGCACTTTCACAAAAAGAATTAGCACAAGCGATTG
GCGTTTCTCAATCTGCAATCGCTCAGATTGAACAACGCGGAAATGATGTGAAACTTTCTACGCTTAAACGCTACATTGAG
AAAATGGGCGGTGAATTAAGCTTAACCGTCAAAATGCCTACGGGTTATAGCCAAATTTTTCCACTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0F5ET33

Antitoxin

Source ID Structure
AlphaFold DB A0A0F5EZ21

References