Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 2741334..2741983 Replicon chromosome
Accession NZ_CP034105
Organism Proteus sp. GOKU

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag EHE21_RS12830 Protein ID WP_194950860.1
Coordinates 2741334..2741684 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag EHE21_RS12835 Protein ID WP_194950861.1
Coordinates 2741684..2741983 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EHE21_RS12805 2736451..2737470 - 1020 WP_194950858.1 thiosulfate ABC transporter substrate-binding protein CysP -
EHE21_RS12810 2737708..2738604 - 897 WP_075670506.1 Dyp-type peroxidase -
EHE21_RS12815 2738725..2739339 - 615 WP_194952663.1 RpoE-regulated lipoprotein -
EHE21_RS12820 2739679..2740116 - 438 WP_075670504.1 GNAT family acetyltransferase -
EHE21_RS12825 2740250..2741158 + 909 WP_194950859.1 oxygen-dependent coproporphyrinogen oxidase -
EHE21_RS12830 2741334..2741684 + 351 WP_194950860.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
EHE21_RS12835 2741684..2741983 + 300 WP_194950861.1 XRE family transcriptional regulator Antitoxin
EHE21_RS12840 2742038..2742364 - 327 WP_194952664.1 hypothetical protein -
EHE21_RS12845 2742569..2744059 - 1491 WP_075670500.1 ribosome biogenesis GTPase Der -
EHE21_RS12850 2744179..2745351 - 1173 WP_194950862.1 outer membrane protein assembly factor BamB -
EHE21_RS12855 2745366..2745986 - 621 WP_194950863.1 YfgM family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-107)

Antitoxin

Cro/C1-type helix-turn-helix domain

(32-80)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 13577.77 Da        Isoelectric Point: 6.9276

>T115241 WP_194950860.1 NZ_CP034105:2741334-2741684 [Proteus sp. GOKU]
MWVVITKLPFEEWFEVQPNYLQDEILAVLCVLRENGPLLGRPYVDTLSGSKFMNMKELRIQVKGQPIRICFAFDNSRQAI
ILCAGNKKGRNEKQFYNNLIKTADEQFRIHLSELEE

Download         Length: 351 bp

>T115241 NZ_CP034105:2741334-2741684 [Proteus sp. GOKU]
ATGTGGGTAGTCATAACAAAATTGCCTTTTGAAGAATGGTTTGAAGTTCAACCAAATTATCTTCAAGACGAAATATTAGC
TGTTCTTTGTGTTCTTCGAGAAAATGGGCCTCTTCTTGGACGCCCTTATGTTGACACTCTTTCTGGATCAAAATTTATGA
ATATGAAAGAGTTAAGAATACAAGTTAAAGGTCAACCTATTAGAATATGTTTCGCATTCGATAATTCTAGGCAAGCAATT
ATCTTATGTGCAGGTAATAAGAAAGGTCGAAATGAAAAACAGTTTTACAATAATCTTATAAAAACAGCAGATGAACAATT
TCGTATTCACCTATCAGAATTGGAGGAGTGA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 11107.03 Da        Isoelectric Point: 10.2867

>AT115241 WP_194950861.1 NZ_CP034105:2741684-2741983 [Proteus sp. GOKU]
MATLDEMLAKRTPDSRKRIEARVKEIQRELTLAKIREELHISQTQLATSLGVKQPAIAKMERVDNDLKISTLKRYVDAIG
GKLAIDITLPNGEKIALNL

Download         Length: 300 bp

>AT115241 NZ_CP034105:2741684-2741983 [Proteus sp. GOKU]
ATGGCAACTTTAGATGAAATGCTAGCAAAAAGAACACCAGATAGTCGTAAAAGAATTGAAGCTAGAGTTAAAGAAATTCA
GCGTGAACTCACATTAGCGAAAATACGAGAAGAACTACATATATCTCAAACCCAGTTAGCAACTTCATTAGGGGTTAAAC
AACCAGCTATCGCCAAAATGGAACGTGTTGATAATGACCTTAAAATCTCAACACTTAAACGCTATGTTGATGCGATAGGT
GGCAAGCTTGCAATTGATATCACATTACCTAATGGTGAAAAAATAGCCCTGAATTTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References