Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 853367..854091 Replicon chromosome
Accession NZ_CP034105
Organism Proteus sp. GOKU

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag EHE21_RS03910 Protein ID WP_194951895.1
Coordinates 853780..854091 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag EHE21_RS03905 Protein ID WP_088493636.1
Coordinates 853367..853783 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EHE21_RS03880 848763..849173 - 411 WP_194951893.1 GNAT family N-acetyltransferase -
EHE21_RS03885 849286..850338 + 1053 WP_088493639.1 AbrB family transcriptional regulator -
EHE21_RS03890 850462..850812 - 351 WP_088493638.1 YacC family pilotin-like protein -
EHE21_RS03895 851026..852606 + 1581 WP_194951894.1 multicopper oxidase CueO -
EHE21_RS03900 852766..853308 + 543 WP_036932823.1 hypoxanthine phosphoribosyltransferase -
EHE21_RS03905 853367..853783 - 417 WP_088493636.1 helix-turn-helix domain-containing protein Antitoxin
EHE21_RS03910 853780..854091 - 312 WP_194951895.1 type II toxin-antitoxin system HigB family toxin Toxin
EHE21_RS03915 854227..854880 - 654 WP_036932822.1 carbonate dehydratase -
EHE21_RS03920 855665..856600 + 936 WP_075674123.1 ABC transporter ATP-binding protein -
EHE21_RS03925 856597..857367 + 771 WP_088493634.1 ABC transporter permease -
EHE21_RS03930 857554..858786 + 1233 WP_109393286.1 MFS transporter -
EHE21_RS03935 858874..859056 + 183 WP_194951896.1 DUF2526 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(20-93)

Antitoxin

Antitoxin HigA

(2-138)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12421.29 Da        Isoelectric Point: 9.6245

>T115238 WP_194951895.1 NZ_CP034105:c854091-853780 [Proteus sp. GOKU]
MHVISREPFDLASIRFPNCAQALTDAYRTLKQNTYQTPEALKKVFPSLDRMKYREKWWVIDIGGNTLRILFFADFERDKI
FVKHISTHAEYDKLIDYYRRTKE

Download         Length: 312 bp

>T115238 NZ_CP034105:c854091-853780 [Proteus sp. GOKU]
ATGCACGTAATATCACGAGAGCCTTTTGATTTAGCATCTATACGTTTCCCCAATTGTGCTCAAGCACTTACCGATGCTTA
TAGAACGCTAAAACAGAATACTTATCAAACACCTGAAGCATTAAAAAAAGTCTTCCCAAGTTTAGATAGGATGAAGTATA
GAGAAAAATGGTGGGTTATCGATATTGGTGGAAATACGCTAAGGATCCTATTTTTTGCGGATTTTGAACGCGACAAAATA
TTTGTGAAACATATTTCTACTCATGCTGAATACGATAAACTCATTGATTACTATCGGAGAACAAAAGAATGA

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15755.03 Da        Isoelectric Point: 4.9794

>AT115238 WP_088493636.1 NZ_CP034105:c853783-853367 [Proteus sp. GOKU]
MMIVDAIKAANSLVNIVPILGRNQSRKDYEEGVKLVEYLVEHDPDNPLIDMLCHKIDEYENSAPEFGAFNARLNQCDDAI
AVLRTLMDQYQLNTTDFKEELGSRSYVSRILNGERNLTLEHIKKLAARFNVPVSIFIK

Download         Length: 417 bp

>AT115238 NZ_CP034105:c853783-853367 [Proteus sp. GOKU]
ATGATGATTGTTGATGCAATTAAGGCTGCTAATAGCCTAGTCAATATAGTTCCTATTCTTGGTCGTAACCAATCTCGTAA
AGACTATGAAGAGGGTGTCAAATTAGTTGAATACTTAGTAGAACACGACCCAGATAATCCTTTAATTGATATGCTTTGTC
ATAAAATTGACGAATATGAAAATAGCGCACCTGAATTTGGAGCTTTCAATGCAAGACTCAATCAATGTGATGATGCAATT
GCAGTTTTGCGCACATTGATGGATCAATATCAGCTAAATACGACTGATTTTAAAGAAGAATTAGGCTCACGCTCTTATGT
AAGTCGTATTCTCAATGGTGAACGTAATCTCACACTAGAGCATATTAAAAAACTGGCAGCTAGATTCAATGTACCTGTGT
CTATTTTTATTAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References