Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2529588..2530105 Replicon chromosome
Accession NZ_CP034102
Organism Staphylococcus aureus strain O267

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag SaO267_RS13365 Protein ID WP_000375483.1
Coordinates 2529588..2529854 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag SaO267_RS13370 Protein ID WP_000584499.1
Coordinates 2529854..2530105 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SaO267_RS13340 2524736..2525272 - 537 WP_000185901.1 GNAT family N-acetyltransferase -
SaO267_RS13345 2525792..2526616 - 825 WP_000594631.1 formate/nitrite transporter family protein -
SaO267_RS13350 2526819..2527001 - 183 WP_000079140.1 hypothetical protein -
SaO267_RS13355 2527088..2527555 - 468 WP_000153340.1 SRPBCC domain-containing protein -
SaO267_RS13360 2527741..2529294 - 1554 WP_000727769.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
SaO267_RS13365 2529588..2529854 - 267 WP_000375483.1 Txe/YoeB family addiction module toxin Toxin
SaO267_RS13370 2529854..2530105 - 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
SaO267_RS13375 2530269..2530369 - 101 Protein_2485 hypothetical protein -
SaO267_RS13380 2530376..2530975 - 600 WP_000162810.1 DsbA family protein -
SaO267_RS13385 2530994..2531356 - 363 WP_000819843.1 DUF4467 domain-containing protein -
SaO267_RS13390 2531611..2532861 + 1251 WP_001012239.1 FemA/FemB family glycyltransferase FmhA -
SaO267_RS13395 2532954..2533685 - 732 WP_000615461.1 amino acid ABC transporter ATP-binding protein -
SaO267_RS13400 2533682..2534401 - 720 WP_000479576.1 amino acid ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(8-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10450.05 Da        Isoelectric Point: 10.2538

>T115232 WP_000375483.1 NZ_CP034102:c2529854-2529588 [Staphylococcus aureus]
MDRLNITFSPQAFADYKYFQQNDKKMVKKINELLKSIDRNGALKGIGKPEKLKSNLTGYYSRRINHEHRLVYKVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T115232 NZ_CP034102:c2529854-2529588 [Staphylococcus aureus]
ATGGATAGGTTAAATATTACGTTTTCGCCTCAAGCCTTTGCAGATTATAAGTATTTTCAGCAGAACGATAAAAAAATGGT
GAAGAAGATTAATGAGTTACTTAAAAGTATTGACAGAAATGGCGCATTGAAAGGTATAGGTAAGCCTGAAAAGTTAAAAT
CGAATCTGACTGGGTATTATAGTAGACGTATCAATCACGAACATAGATTGGTTTATAAAGTAGATGACAATCATATAAAA
ATAGCATCATGTAAATACCATTATTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT115232 WP_000584499.1 NZ_CP034102:c2530105-2529854 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp

>AT115232 NZ_CP034102:c2530105-2529854 [Staphylococcus aureus]
ATGATTATTAAAAATTATTCATACGCTCGACAGAATTTAAAGGCACTTATGACAAAAGTAAATGATGATAGTGATATGGT
AACTGTAACATCTACTGATGATAAAAACGTAGTAATCATGTCAGAATCAGATTATAACTCCATGATGGAAACACTTTACC
TCCAACAGAATCCAAATAATGCTGAACACTTAGCTCAATCAATTGCAGATCTAGAACGTGGGAAAACTATAACGAAAGAT
ATAGATGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7BWF
PDB 6L8E
AlphaFold DB T1YB60

References