Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) sprG-sprF/-
Location 2264614..2264877 Replicon chromosome
Accession NZ_CP034102
Organism Staphylococcus aureus strain O267

Toxin (Protein)


Gene name SprG3 Uniprot ID Q2FWA7
Locus tag SaO267_RS11965 Protein ID WP_001802298.1
Coordinates 2264773..2264877 (-) Length 35 a.a.

Antitoxin (RNA)


Gene name SprF2
Locus tag -
Coordinates 2264614..2264778 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SaO267_RS11945 2260788..2261453 - 666 WP_001024100.1 SDR family oxidoreductase -
SaO267_RS11950 2261605..2261925 + 321 WP_000003759.1 Zn(II)-responsive metalloregulatory transcriptional repressor CzrA -
SaO267_RS11955 2261927..2262907 + 981 WP_000019740.1 CDF family zinc efflux transporter CzrB -
SaO267_RS11960 2263173..2264264 + 1092 WP_000495692.1 hypothetical protein -
- 2264614..2264778 + 165 - - Antitoxin
SaO267_RS11965 2264773..2264877 - 105 WP_001802298.1 hypothetical protein Toxin
SaO267_RS15065 2265038..2265521 - 484 Protein_2223 recombinase family protein -
SaO267_RS11975 2265564..2266684 - 1121 Protein_2224 SAP domain-containing protein -
SaO267_RS11980 2267733..2268590 - 858 WP_000370943.1 Cof-type HAD-IIB family hydrolase -
SaO267_RS11985 2268658..2269440 - 783 WP_000909235.1 ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Holin

(3-68)


Sequences

Toxin        


Download         Length: 35 a.a.        Molecular weight: 3906.77 Da        Isoelectric Point: 5.5724

>T115230 WP_001802298.1 NZ_CP034102:c2264877-2264773 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Download         Length: 105 bp

>T115230 NZ_CP034102:c2264877-2264773 [Staphylococcus aureus]
TTGTTACTCCTAGAAAGGACTAGCATGTCTGATTTTGAAATGCTGATGGTTGTATTAACAATCATTGGTTTAGTATTGAT
TAGTACTCAAGACCATAAAAAATAA

Antitoxin


Download         Length: 165 bp

>AT115230 NZ_CP034102:2264614-2264778 [Staphylococcus aureus]
GTAGTAAGTAGAAGCAAAAGATGAAAATCTTTAACTCTTGAAACACAAAAAGGGCAACACTCGGAAACATGTTACCCTAA
TGAGCCCGTTAAAAAGACGGTGACCTTATATTTTATTTAAAAATAGCCTTCAAAAATGCCGGTCAAAGCGAATAGAAGGT
TATTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2I7Y9L9

Antitoxin

Download structure file

References