Detailed information of TA system TA115225

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprA1-sprA1AS/-
• Location: 1903803..1903983
• Replicon: chromosome
• Accession: NZ_CP034102
• Organism: Staphylococcus aureus strain O267

Toxin (Protein)

• Gene name: sprA1
• Uniprot ID: -
• Locus tag: SaO267_RS09685
• Protein ID: WP_001801861.1
• Coordinates: 1903803..1903898 (+)
• Length: 32 a.a.

Antitoxin (RNA)

Gene name	sprA1AS
Locus tag	-
Coordinates	1903926..1903983 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SaO267_RS09650	1899207..1899833	+	627	WP_000669034.1	hypothetical protein	-
SaO267_RS09655	1899874..1900215	+	342	WP_000627544.1	DUF3969 family protein	-
SaO267_RS09660	1900316..1900888	+	573	WP_000414210.1	hypothetical protein	-
SaO267_RS09665	1901264..1902100	+	837	WP_000190484.1	ABC transporter ATP-binding protein	-
SaO267_RS09675	1902906..1903352	-	447	WP_000747806.1	DUF1433 domain-containing protein	-
SaO267_RS09685	1903803..1903898	+	96	WP_001801861.1	type I toxin-antitoxin system Fst family toxin PepA1	Toxin
-	1903926..1903983	-	58	-	-	Antitoxin
SaO267_RS09690	1904021..1904122	+	102	WP_001791232.1	hypothetical protein	-
SaO267_RS09695	1904108..1904287	-	180	Protein_1831	transposase	-
SaO267_RS09700	1904475..1904849	-	375	WP_000695817.1	DUF1433 domain-containing protein	-
SaO267_RS09705	1904839..1905219	-	381	WP_001035978.1	DUF1433 domain-containing protein	-
SaO267_RS09710	1905427..1905867	-	441	WP_000759945.1	DUF1433 domain-containing protein	-
SaO267_RS09715	1905912..1907525	+	1614	WP_000926709.1	hypothetical protein	-
SaO267_RS09720	1907540..1907839	+	300	WP_000095391.1	WXG100 family type VII secretion target	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 32 a.a.
• Molecular weight: 3554.32 Da
• Isoelectric Point: 10.4449

>T115225 WP_001801861.1 NZ_CP034102:1903803-1903898 [Staphylococcus aureus]
VMLIFVHIIAPVISGCAIAFFSYWLSRRNTK

Nucleotide

• Length: 96 bp

>T115225 NZ_CP034102:1903803-1903898 [Staphylococcus aureus]
GTGATGCTTATTTTCGTTCACATCATAGCACCAGTCATCAGTGGCTGTGCCATTGCGTTTTTTTCTTATTGGCTAAGTAG
ACGCAATACAAAATAG

Antitoxin

Nucleotide

• Length: 58 bp

>AT115225 NZ_CP034102:c1903983-1903926 [Staphylococcus aureus]
AACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Structures

Antitoxin