Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2438361..2438884 Replicon chromosome
Accession NZ_CP034098
Organism Staphylococcus aureus strain 80wphwpl_v1

Toxin (Protein)


Gene name yoeB Uniprot ID A0A2W3LFI1
Locus tag EHS18_RS12385 Protein ID WP_000074047.1
Coordinates 2438361..2438627 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A2S6D1W5
Locus tag EHS18_RS12390 Protein ID WP_000587617.1
Coordinates 2438627..2438884 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EHS18_RS12365 2433571..2434758 - 1188 WP_000026190.1 MFS transporter -
EHS18_RS12370 2435152..2435928 - 777 WP_000072154.1 iron export ABC transporter permease subunit FetB -
EHS18_RS12375 2435921..2436583 - 663 WP_000923514.1 ATP-binding cassette domain-containing protein -
EHS18_RS12380 2436929..2438005 - 1077 WP_001076679.1 M42 family metallopeptidase -
EHS18_RS12385 2438361..2438627 - 267 WP_000074047.1 Txe/YoeB family addiction module toxin Toxin
EHS18_RS12390 2438627..2438884 - 258 WP_000587617.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
EHS18_RS12400 2439244..2439699 + 456 WP_000732090.1 YehR family lipoprotein -
EHS18_RS12405 2439867..2441444 - 1578 WP_124733838.1 FMN-binding glutamate synthase family protein -
EHS18_RS12410 2441640..2442389 + 750 WP_000072447.1 CPBP family intramembrane metalloprotease -
EHS18_RS12415 2442613..2443806 - 1194 WP_000675407.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(4-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10662.26 Da        Isoelectric Point: 10.1384

>T115218 WP_000074047.1 NZ_CP034098:c2438627-2438361 [Staphylococcus aureus]
MSNYTVKIKNSAKSDLKKIKHSYLKKSFLEIVETLKNDPYKITQSFEKLEPKYLERYSRRINHQHRIVYTVDDRNKEVLI
LSAWSHYD

Download         Length: 267 bp

>T115218 NZ_CP034098:c2438627-2438361 [Staphylococcus aureus]
ATGAGCAATTACACGGTTAAGATTAAAAATTCAGCGAAATCAGATTTAAAGAAAATAAAACATTCTTATTTAAAGAAGTC
ATTTTTAGAAATTGTTGAGACTTTAAAAAATGATCCGTATAAAATAACACAATCCTTTGAAAAATTAGAACCTAAATATT
TAGAGCGATATTCAAGAAGAATTAACCATCAGCACAGGATCGTCTATACCGTAGATGATCGAAATAAAGAAGTATTAATA
CTATCGGCATGGTCACATTATGATTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9747.71 Da        Isoelectric Point: 4.1353

>AT115218 WP_000587617.1 NZ_CP034098:c2438884-2438627 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETIYLESTGTMDKVREREKDSSGTTNIDDI
DWDNL

Download         Length: 258 bp

>AT115218 NZ_CP034098:c2438884-2438627 [Staphylococcus aureus]
ATGATTATCACTAGCCCTACAGAAGCGAGAAAAGATTTTTATCAATTACTAAAAAATGTTAATAATAATCACGAACCAAT
TTATATTAGTGGCAATAATGCCGAAAATAATGCTGTGATTATAGGTTTAGAAGATTGGAAAAGTATACAAGAGACAATAT
ATCTTGAATCTACTGGTACAATGGACAAAGTAAGAGAAAGAGAAAAAGATAGTAGTGGTACAACAAATATAGATGATATT
GATTGGGATAATCTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2W3LFI1

Antitoxin

Source ID Structure
AlphaFold DB A0A2S6D1W5

References