Detailed information of TA system TA115205

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/COG4683-HTH_37
• Location: 19411..20062
• Replicon: plasmid pA52-2
• Accession: NZ_CP034094
• Organism: Acinetobacter baumannii strain A52

Toxin (Protein)

• Gene name: higB
• Uniprot ID: V2UF49
• Locus tag: EHF38_RS19290
• Protein ID: WP_000269909.1
• Coordinates: 19706..20062 (-)
• Length: 119 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: EHF38_RS19285
• Protein ID: WP_001140621.1
• Coordinates: 19411..19713 (-)
• Length: 101 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EHF38_RS19245	15099..15802	+	704	Protein_16	IS6-like element IS1008 family transposase	-
EHF38_RS19260	16441..16686	+	246	WP_000246756.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	-
EHF38_RS19265	16676..16969	+	294	WP_000221358.1	type II toxin-antitoxin system RelE/ParE family toxin	-
EHF38_RS19270	17133..18083	+	951	WP_128385926.1	DUF4062 domain-containing protein	-
EHF38_RS19665	18316..18477	-	162	WP_213075440.1	hypothetical protein	-
EHF38_RS19275	18461..19090	-	630	WP_128385927.1	hypothetical protein	-
EHF38_RS19280	19209..19418	-	210	WP_000069472.1	hypothetical protein	-
EHF38_RS19285	19411..19713	-	303	WP_001140621.1	XRE family transcriptional regulator	Antitoxin
EHF38_RS19290	19706..20062	-	357	WP_000269909.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
EHF38_RS19295	20683..21372	+	690	WP_128385928.1	hypothetical protein	-
EHF38_RS19300	21638..21946	-	309	WP_000244382.1	helix-turn-helix domain-containing protein	-
EHF38_RS19305	21933..22250	-	318	WP_000288000.1	hypothetical protein	-
EHF38_RS19310	22496..22912	+	417	WP_000754614.1	hypothetical protein	-
EHF38_RS19315	23011..23256	-	246	WP_000218068.1	hypothetical protein	-
EHF38_RS19320	23342..23677	-	336	WP_111097473.1	hypothetical protein	-
EHF38_RS19325	24267..24524	-	258	WP_111097478.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..27452	27452

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (12-106)

Antitoxin

• HigA2-like, helix-turn-helix domain (14-89)

Sequences

Toxin

Protein

• Length: 119 a.a.
• Molecular weight: 13515.49 Da
• Isoelectric Point: 6.4631

>T115205 WP_000269909.1 NZ_CP034094:c20062-19706 [Acinetobacter baumannii]
MWTVITTDLFNEWLVQQDESTQEKVLAALVVLQQQGPSLGRPLVDTVYDSKFTNMKELRVQHRGKPLRAFFAFDPLRQAI
VLCIGDKGGKKRFYKEMLDIADQQYELHLSTLGDQSNG

Nucleotide

• Length: 357 bp

>T115205 NZ_CP034094:c20062-19706 [Acinetobacter baumannii]
ATGTGGACAGTCATTACAACGGATCTGTTTAACGAATGGCTTGTACAGCAAGATGAATCTACACAAGAGAAAGTACTCGC
AGCGTTGGTCGTTCTACAGCAACAGGGACCAAGTTTAGGTCGTCCTTTAGTAGATACCGTCTATGACTCCAAATTTACCA
ACATGAAAGAGCTACGTGTTCAGCATCGAGGTAAACCACTGAGAGCCTTTTTCGCATTTGATCCTTTACGACAAGCTATT
GTGCTGTGTATCGGTGATAAAGGCGGTAAAAAGCGTTTTTATAAAGAGATGTTAGATATTGCCGATCAGCAATACGAACT
TCATCTTTCAACTTTAGGAGATCAATCTAATGGCTAA

Antitoxin

Protein

• Length: 101 a.a.
• Molecular weight: 11179.02 Da
• Isoelectric Point: 7.3198

>AT115205 WP_001140621.1 NZ_CP034094:c19713-19411 [Acinetobacter baumannii]
MAKTLQELLASRSPESQARIQKMADELLLETQLHLIREELEISQKELAATLGIKQPSLSAIENRGHDLKISTMKKYVEAM
GGKLRIDVELPTGKHIGFNV

Nucleotide

• Length: 303 bp

>AT115205 NZ_CP034094:c19713-19411 [Acinetobacter baumannii]
ATGGCTAAGACCCTACAAGAATTATTGGCTAGTCGCTCTCCAGAGAGTCAAGCTCGTATTCAAAAAATGGCTGATGAATT
ACTGTTGGAAACTCAGCTTCACCTTATTCGTGAAGAGTTAGAGATTTCTCAAAAAGAACTGGCTGCAACCCTTGGAATCA
AACAGCCGTCATTGTCAGCAATCGAAAATCGTGGTCATGATCTTAAAATTTCAACGATGAAAAAGTATGTTGAAGCAATG
GGCGGAAAACTTCGTATTGATGTAGAGCTTCCAACAGGAAAACACATAGGATTTAATGTCTAA

Structures

Toxin

• AlphaFold DB: V2UF49