Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 2839304..2839915 Replicon chromosome
Accession NZ_CP034086
Organism Methylocystis rosea strain GW6

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag EHO51_RS13695 Protein ID WP_124739348.1
Coordinates 2839619..2839915 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag EHO51_RS13690 Protein ID WP_124739347.1
Coordinates 2839304..2839612 (-) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EHO51_RS13670 2834515..2835225 - 711 WP_124740166.1 invasion associated locus B family protein -
EHO51_RS13675 2835536..2837422 + 1887 WP_124739344.1 extracellular solute-binding protein -
EHO51_RS13680 2837604..2838593 + 990 WP_124739345.1 paraslipin -
EHO51_RS13685 2838597..2839061 + 465 WP_124739346.1 NfeD family protein -
EHO51_RS13690 2839304..2839612 - 309 WP_124739347.1 HigA family addiction module antidote protein Antitoxin
EHO51_RS13695 2839619..2839915 - 297 WP_124739348.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
EHO51_RS13700 2840058..2841836 + 1779 WP_124739349.1 DNA mismatch repair endonuclease MutL -
EHO51_RS13705 2841932..2842441 + 510 WP_124740167.1 peptide-methionine (R)-S-oxide reductase MsrB -
EHO51_RS13710 2842453..2843130 + 678 WP_124739350.1 peptide-methionine (S)-S-oxide reductase MsrA -
EHO51_RS13715 2843224..2844465 - 1242 WP_124739351.1 GSCFA domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-97)

Antitoxin

Cro/C1-type helix-turn-helix domain

(25-69)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11590.12 Da        Isoelectric Point: 6.2275

>T115190 WP_124739348.1 NZ_CP034086:c2839915-2839619 [Methylocystis rosea]
MIVSFRDDWLRNFFVDDLRSKKIPPELDGRLFRKIQMIDDATTDQDLRVPPSNHFEKLRGALEGLHSIRVNKQWRLIFEW
NGATGEAKALYLDDHSYD

Download         Length: 297 bp

>T115190 NZ_CP034086:c2839915-2839619 [Methylocystis rosea]
ATGATCGTGAGTTTTCGGGATGACTGGCTGCGCAATTTTTTCGTCGACGACCTTCGGTCAAAGAAAATTCCTCCCGAACT
TGATGGCCGTCTTTTTCGAAAGATTCAGATGATCGACGATGCGACGACGGATCAGGATCTGCGTGTTCCGCCCAGCAATC
ATTTCGAAAAGCTCCGCGGTGCGCTCGAAGGTTTACATTCAATCCGGGTCAATAAGCAGTGGCGGCTGATCTTCGAATGG
AACGGCGCGACGGGAGAAGCGAAGGCCCTTTATCTCGATGATCACAGCTATGATTGA

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11553.46 Da        Isoelectric Point: 10.9969

>AT115190 WP_124739347.1 NZ_CP034086:c2839612-2839304 [Methylocystis rosea]
MLTTKRKPASVGEILTEEFMIPSRLTQVALADAMGVQRKHVNELCNDRRAVTAPTALILARVFGNSPEFWLNVQRRSDLW
EAMHSPKERERIARAKPLKSVA

Download         Length: 309 bp

>AT115190 NZ_CP034086:c2839612-2839304 [Methylocystis rosea]
ATGCTGACAACGAAACGCAAGCCGGCGAGCGTCGGCGAGATCCTTACTGAAGAGTTCATGATCCCTTCGAGGCTCACGCA
GGTCGCATTGGCGGACGCCATGGGCGTTCAGCGCAAACACGTCAATGAACTCTGTAATGATCGGCGAGCTGTCACCGCGC
CGACGGCGCTTATTCTCGCGCGGGTTTTTGGCAACAGCCCGGAGTTTTGGCTGAACGTGCAGCGCCGCAGCGATTTGTGG
GAGGCGATGCACTCGCCCAAGGAGCGCGAGCGTATCGCCCGCGCCAAGCCGCTCAAATCTGTGGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References