Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 3964616..3965223 Replicon chromosome
Accession NZ_CP034058
Organism Anabaena sp. YBS01

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag EH233_RS16760 Protein ID WP_011319973.1
Coordinates 3964939..3965223 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag EH233_RS16755 Protein ID WP_011319974.1
Coordinates 3964616..3964924 (-) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EH233_RS16740 3960771..3961700 - 930 WP_011319977.1 caspase family protein -
EH233_RS16745 3961807..3962031 + 225 WP_153228420.1 hypothetical protein -
EH233_RS16750 3962188..3964587 + 2400 WP_011319975.1 NACHT domain-containing NTPase -
EH233_RS16755 3964616..3964924 - 309 WP_011319974.1 HigA family addiction module antidote protein Antitoxin
EH233_RS16760 3964939..3965223 - 285 WP_011319973.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
EH233_RS16765 3965441..3965872 + 432 WP_011319972.1 hypothetical protein -
EH233_RS16770 3966092..3966679 - 588 WP_011319971.1 hypothetical protein -
EH233_RS16775 3966847..3967002 - 156 WP_011319970.1 hypothetical protein -
EH233_RS16780 3967081..3969924 - 2844 WP_011319969.1 DUF3987 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(5-94)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-95)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10826.24 Da        Isoelectric Point: 5.0914

>T115067 WP_011319973.1 NZ_CP034058:c3965223-3964939 [Anabaena sp. YBS01]
VIVNFKSEETKLIFEGFTSSQYPPNIQKTALRKLLILDAATSINDLRVPPGNRLEKLVGDRSGQYSIRINDQWRICFVWT
DENNASEVEIVDYH

Download         Length: 285 bp

>T115067 NZ_CP034058:c3965223-3964939 [Anabaena sp. YBS01]
GTGATTGTTAATTTCAAGTCTGAAGAGACAAAGCTAATTTTTGAAGGCTTTACATCTTCTCAATACCCACCCAATATTCA
GAAGACTGCTTTACGAAAACTACTTATCCTTGATGCAGCAACATCAATTAATGACTTACGCGTCCCACCAGGAAATCGCC
TAGAAAAGCTAGTTGGCGATAGAAGTGGCCAGTACAGTATTCGGATTAATGACCAATGGCGGATTTGCTTTGTTTGGACA
GATGAAAACAATGCTTCGGAAGTTGAAATAGTCGATTACCACTAA

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11699.17 Da        Isoelectric Point: 5.6642

>AT115067 WP_011319974.1 NZ_CP034058:c3964924-3964616 [Anabaena sp. YBS01]
MNNNRLPNIHPGEILKLDFLEPLNITAYRLSKDIGVTQTRISEILSGKRSITADTALRLSHYFGNTAQFWLNLQTQYDLR
QALEENSEVYNQISKFLSDDVA

Download         Length: 309 bp

>AT115067 NZ_CP034058:c3964924-3964616 [Anabaena sp. YBS01]
ATGAATAACAACCGTTTGCCAAACATTCATCCAGGTGAAATCCTAAAACTAGACTTTTTAGAACCGTTGAATATCACAGC
TTATCGATTAAGCAAAGATATAGGTGTAACTCAGACACGAATTAGTGAAATTTTATCTGGAAAACGGAGTATTACGGCTG
ATACAGCTTTGCGTCTATCCCACTATTTTGGCAACACCGCCCAGTTTTGGTTAAATTTACAAACACAATATGATTTACGT
CAAGCCCTTGAAGAAAATTCAGAAGTTTATAATCAAATTTCTAAATTTCTGTCTGATGATGTAGCCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References