Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) SprA2-SprA2AS/-
Location 2504532..2504716 Replicon chromosome
Accession NZ_CP034008
Organism Staphylococcus aureus strain P1D5C2

Toxin (Protein)


Gene name SprA2 Uniprot ID A0A2U0ISP5
Locus tag EFD69_RS12535 Protein ID WP_000482652.1
Coordinates 2504609..2504716 (-) Length 36 a.a.

Antitoxin (RNA)


Gene name SprA2AS
Locus tag -
Coordinates 2504532..2504592 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EFD69_RS12520 2499987..2500154 - 168 Protein_2401 hypothetical protein -
EFD69_RS12525 2500385..2502118 - 1734 WP_000486487.1 ABC transporter ATP-binding protein/permease -
EFD69_RS12530 2502143..2503906 - 1764 WP_001064825.1 ABC transporter ATP-binding protein/permease -
- 2504532..2504592 + 61 - - Antitoxin
EFD69_RS12535 2504609..2504716 - 108 WP_000482652.1 type I toxin-antitoxin system Fst family toxin Toxin
EFD69_RS12540 2504850..2505236 - 387 WP_000779360.1 flippase GtxA -
EFD69_RS12545 2505504..2506646 + 1143 WP_001176863.1 glycerate kinase -
EFD69_RS12550 2506706..2507365 + 660 WP_000831298.1 membrane protein -
EFD69_RS12555 2507547..2508758 + 1212 WP_156668050.1 multidrug effflux MFS transporter -
EFD69_RS12560 2508881..2509354 - 474 WP_000456486.1 GyrI-like domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 4011.78 Da        Isoelectric Point: 11.0582

>T114919 WP_000482652.1 NZ_CP034008:c2504716-2504609 [Staphylococcus aureus]
MFNLLINIMTSALSGCLVAFFAHWLRTRNNKKGDK

Download         Length: 108 bp

>T114919 NZ_CP034008:c2504716-2504609 [Staphylococcus aureus]
ATGTTCAATTTATTAATTAACATCATGACTTCAGCTTTAAGCGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAACAATAAAAAAGGTGACAAATAA

Antitoxin


Download         Length: 61 bp

>AT114919 NZ_CP034008:2504532-2504592 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2U0ISP5

Antitoxin

Download structure file

References