Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) sprG-sprF/-
Location 2219532..2219748 Replicon chromosome
Accession NZ_CP034008
Organism Staphylococcus aureus strain P1D5C2

Toxin (Protein)


Gene name SprG3 Uniprot ID Q2FWA7
Locus tag EFD69_RS11045 Protein ID WP_001802298.1
Coordinates 2219644..2219748 (-) Length 35 a.a.

Antitoxin (RNA)


Gene name SprF1
Locus tag -
Coordinates 2219532..2219587 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EFD69_RS11025 2215738..2216403 - 666 WP_001024095.1 SDR family oxidoreductase -
EFD69_RS11030 2216555..2216875 + 321 WP_000003759.1 Zn(II)-responsive metalloregulatory transcriptional repressor CzrA -
EFD69_RS11035 2216877..2217854 + 978 WP_000019734.1 CDF family zinc efflux transporter CzrB -
EFD69_RS11040 2218120..2219211 + 1092 WP_156668041.1 transcriptional regulator -
- 2219532..2219587 + 56 - - Antitoxin
EFD69_RS11045 2219644..2219748 - 105 WP_001802298.1 hypothetical protein Toxin
EFD69_RS11055 2220428..2220586 + 159 WP_001792784.1 hypothetical protein -
EFD69_RS11060 2221244..2222101 - 858 WP_000370923.1 Cof-type HAD-IIB family hydrolase -
EFD69_RS11065 2222169..2222951 - 783 WP_000908182.1 ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 35 a.a.        Molecular weight: 3906.77 Da        Isoelectric Point: 5.5724

>T114916 WP_001802298.1 NZ_CP034008:c2219748-2219644 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Download         Length: 105 bp

>T114916 NZ_CP034008:c2219748-2219644 [Staphylococcus aureus]
TTGTTACTCCTAGAAAGGACTAGCATGTCTGATTTTGAAATGCTGATGGTTGTATTAACAATCATTGGTTTAGTATTGAT
TAGTACTCAAGACCATAAAAAATAA

Antitoxin


Download         Length: 56 bp

>AT114916 NZ_CP034008:2219532-2219587 [Staphylococcus aureus]
AAAAAGGGCAACACTCGGAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2I7Y9L9

Antitoxin

Download structure file

References