Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) SprA2-SprA2AS/-
Location 2504531..2504715 Replicon chromosome
Accession NZ_CP034005
Organism Staphylococcus aureus strain P1D7C1

Toxin (Protein)


Gene name SprA2 Uniprot ID A0A2U0ISP5
Locus tag EFD70_RS12520 Protein ID WP_000482652.1
Coordinates 2504608..2504715 (-) Length 36 a.a.

Antitoxin (RNA)


Gene name SprA2AS
Locus tag -
Coordinates 2504531..2504591 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EFD70_RS12505 2499986..2500153 - 168 Protein_2407 hypothetical protein -
EFD70_RS12510 2500384..2502117 - 1734 WP_000486487.1 ABC transporter ATP-binding protein/permease -
EFD70_RS12515 2502142..2503905 - 1764 WP_001064825.1 ABC transporter ATP-binding protein/permease -
- 2504531..2504591 + 61 - - Antitoxin
EFD70_RS12520 2504608..2504715 - 108 WP_000482652.1 type I toxin-antitoxin system Fst family toxin Toxin
EFD70_RS12525 2504849..2505235 - 387 WP_000779360.1 flippase GtxA -
EFD70_RS12530 2505503..2506645 + 1143 WP_001176863.1 glycerate kinase -
EFD70_RS12535 2506705..2507364 + 660 WP_000831298.1 membrane protein -
EFD70_RS12540 2507546..2508757 + 1212 WP_156668050.1 multidrug effflux MFS transporter -
EFD70_RS12545 2508880..2509353 - 474 WP_000456486.1 GyrI-like domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-116)


Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 4011.78 Da        Isoelectric Point: 11.0582

>T114901 WP_000482652.1 NZ_CP034005:c2504715-2504608 [Staphylococcus aureus]
MFNLLINIMTSALSGCLVAFFAHWLRTRNNKKGDK

Download         Length: 108 bp

>T114901 NZ_CP034005:c2504715-2504608 [Staphylococcus aureus]
ATGTTCAATTTATTAATTAACATCATGACTTCAGCTTTAAGCGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAACAATAAAAAAGGTGACAAATAA

Antitoxin


Download         Length: 61 bp

>AT114901 NZ_CP034005:2504531-2504591 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2U0ISP5

Antitoxin

Download structure file

References